Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy

Muhammad Babar Khawar, Chao Liu, Fengyi Gao, Hui Gao, Wenwen Liu, Tingting Han, Lina Wang, Guoping Li, Hui Jiang, Wei Li

PDF(1904 KB)
PDF(1904 KB)
Protein Cell ›› 2021, Vol. 12 ›› Issue (1) : 67-75. DOI: 10.1007/s13238-020-00771-1
LETTER

Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy

Author information +
History +

Cite this article

Download citation ▾
Muhammad Babar Khawar, Chao Liu, Fengyi Gao, Hui Gao, Wenwen Liu, Tingting Han, Lina Wang, Guoping Li, Hui Jiang, Wei Li. Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy. Protein Cell, 2021, 12(1): 67‒75 https://doi.org/10.1007/s13238-020-00771-1

References

[1]
Bilińska B (1994) Staining with ANS fluorescent dye reveals distribution of mitochondria and lipid droplets in cultured Leydig cells. Folia histochemica et cytobiologica 32:21–24
[2]
Chang C, Su H, Zhang D, Wang Y, Shen Q,Liu B, Huang R, Zhou T, Peng C, Wong CC (2015) AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation. Molecular cell 60:930–940
CrossRef Google scholar
[3]
Chen H, Ge R-S, Zirkin BR (2009) Leydig cells: from stem cells to aging. Molecular and cellular endocrinology 306:9–16
CrossRef Google scholar
[4]
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B,Howitz KT, Gorospe M, de Cabo R, Sinclair DA (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390–392
CrossRef Google scholar
[5]
Danielsen ET, Moeller ME, Yamanaka N, Ou Q, Laursen JM, Soenderholm C, Zhuo R, Phelps B, Tang K, Zeng J (2016) A Drosophila genome-wide screen identifies regulators of steroid hormone production and developmental timing. Developmental cell 37:558–570
CrossRef Google scholar
[6]
Gao F, Li G, Liu C, Gao H, Wang H, Liu W, Chen M, Shang Y, Wang L, Shi J (2018) Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. J Cell Biol 217:2103–2119
CrossRef Google scholar
[7]
Hu J, Zhang Z, Shen W-J, Azhar S (2010) Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutrition & metabolism 7:47
CrossRef Google scholar
[8]
Klinefelter GR, Hall PF, Ewing LL (1987) Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure. Biology of Reproduction 36:769–783
CrossRef Google scholar
[9]
Kolthur-Seetharam U, Teerds K, de Rooij DG, Wendling O, McBurney M, Sassone-Corsi P,Davidson I (2009) The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling. Biology of reproduction 80:384–391
CrossRef Google scholar
[10]
Liu C, Wang H, Shang Y, Liu W, Song Z, Zhao H, Wang L, Jia P, Gao F, Xu Z (2016) Autophagy is required for ectoplasmic specialization assembly in sertoli cells. Autophagy 12:814–832
CrossRef Google scholar
[11]
Liu C, Song Z, Wang L, Yu H, Liu W, Shang Y, Xu Z, Zhao H, Gao F, Wen J (2017) Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice. Development 144:441–451
CrossRef Google scholar
[12]
Midzak AS, Chen H, Papadopoulos V, Zirkin BR (2009) Leydig cell aging and the mechanisms of reduced testosterone synthesis. Molecular and cellular endocrinology 299:23–31
CrossRef Google scholar
[13]
Ouimet M, Barrett TJ, Fisher EA (2019) HDL and Reverse Cholesterol Transport: Basic Mechanisms and Their Roles in Vascular Health and Disease. Circulation research 124:1505–1518
CrossRef Google scholar
[14]
Shi X, Sun R, Zhao Y, Fu R, Wang R, Zhao H, Wang Z, Tang F, Zhang N, Tian X (2018) Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease. RSC advances 8:20411–20422
CrossRef Google scholar
[15]
Sinclair M, Grossmann M, Gow PJ, Angus PW (2015) Testosterone in men with advanced liver disease: abnormalities and implications. Journal of gastroenterology and hepatology 30:244–251
CrossRef Google scholar
[16]
Swee DS, Gan E (2019) Late-onset hypogonadism as primary testicular failure. Frontiers in Endocrinology 10:372
CrossRef Google scholar

RIGHTS & PERMISSIONS

2020 The Author(s) 2020
AI Summary AI Mindmap
PDF(1904 KB)

Accesses

Citations

Detail

Sections
Recommended

/