Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Hanbo Li; Xiaoyu Wei; Li Zhou; Weiqi Zhang; Chen Wang; Yang Guo; Denghui Li; Jianyang Chen; Tianbin Liu; Yingying Zhang; Shuai Ma; Congyan Wang; Fujian Tan; Jiangshan Xu; Yang Liu; Yue Yuan; Liang Chen; Qiaoran Wang; Jing Qu; Yue Shen; Shanshan Liu; Guangyi Fan; Longqi Liu; Xin Liu; Yong Hou; Guang-Hui Liu; Ying Gu; Xun Xu

doi:10.1007/s13238-020-00763-1

PDF(4330 KB)

Protein Cell ›› 2021, Vol. 12 ›› Issue (1) : 57-66. DOI: 10.1007/s13238-020-00763-1

LETTER

Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Hanbo Li¹^,² ,
Xiaoyu Wei¹^,³^,⁴ ,
Li Zhou¹^,² ,
Weiqi Zhang⁵^,⁶^,⁷ ,
Chen Wang¹^,² ,
Yang Guo² ,
Denghui Li² ,
Jianyang Chen² ,
Tianbin Liu¹^,⁴^,⁸ ,
Yingying Zhang² ,
Shuai Ma⁶^,⁷^,⁹ ,
Congyan Wang² ,
Fujian Tan² ,
Jiangshan Xu¹^,³^,⁴ ,
Yang Liu¹^,³^,⁴ ,
Yue Yuan¹^,³^,⁴ ,
Liang Chen¹⁰ ,
Qiaoran Wang⁵^,⁶ ,
Jing Qu⁶^,⁷^,¹¹ ,
Yue Shen¹^,⁴^,⁸ ,
Shanshan Liu¹^,² ,
Guangyi Fan¹^,² ,
Longqi Liu¹^,⁴ ,
Xin Liu¹^,² ,
Yong Hou¹^,⁴ ,
Guang-Hui Liu⁶^,⁷^,¹² ,
Ying Gu¹^,⁴^,⁸ ,
Xun Xu¹^,⁴^,⁷^,⁸^,¹³

Author information +

History +

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Hanbo Li, Xiaoyu Wei, Li Zhou, Weiqi Zhang, Chen Wang, Yang Guo, Denghui Li, Jianyang Chen, Tianbin Liu, Yingying Zhang, Shuai Ma, Congyan Wang, Fujian Tan, Jiangshan Xu, Yang Liu, Yue Yuan, Liang Chen, Qiaoran Wang, Jing Qu, Yue Shen, Shanshan Liu, Guangyi Fan, Longqi Liu, Xin Liu, Yong Hou, Guang-Hui Liu, Ying Gu, Xun Xu. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis. Protein Cell, 2021, 12(1): 57‒66 https://doi.org/10.1007/s13238-020-00763-1

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Doyle SL, O'Neill LA (2006) Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 72:1102–1113 CrossRef Google scholar

[2]	Erickson JR, Gearhart MD, Honson DD, Reid TA, Gardner MK, Moriarity BS, Echeverri K (2016) A novel role for SALL4 during scar-free wound healing in axolotl. NPJ Regener Med 1:1–11 CrossRef Google scholar

[3]	Forte E, Chimenti I, Rosa P, Angelini F, Pagano F, Calogero A, Giacomello A, Messina E (2017) EMT/MET at the crossroad of stemness, regeneration and oncogenesis: he Ying-Yang equilibrium recapitulated in cell spheroids. Cancers 9:98 CrossRef Google scholar

[4]	Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, Gac-Santel M, Nowoshilow S, Kageyama J, Khattak (2018). Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science (New York, NY) 362 CrossRef Google scholar

[5]	Godwin JW, Pinto AR, Rosenthal NA (2013) Macrophages are required for adult salamander limb regeneration. Proc Natl Acad Sci USA 110:9415–9420 CrossRef Google scholar

[6]	Haas BJ, Whited JL (2017) Advances in decoding axolotl limb regeneration. Trends Genet 33:553–565 CrossRef Google scholar

[7]	Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Investig 119:1420–1428 CrossRef Google scholar

[8]	Leigh ND, Dunlap GS, Johnson K, Mariano R, Oshiro R, Wong AY, Bryant DM, Miller BM, Ratner A, Chen A (2018) Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution. Nat Commun 9:5153 CrossRef Google scholar

[9]	Marwick JA, Mills R, Kay O, Michail K, Stephen J, Rossi AG, Dransfield I, Hirani N (2018) Neutrophils induce macrophage antiinflammatory reprogramming by suppressing NF-κB activation. Cell Death Dis 9:665 CrossRef Google scholar

[10]	Meng XM, Nikolic-Paterson DJ, Lan HY (2016) TGF-beta: the master regulator of fibrosis. Nat Rev Nephrol 12:325–338 CrossRef Google scholar

[11]	Rayagiri SS, Ranaldi D, Raven A, Mohamad Azhar NIF, Lefebvre O, Zammit PS, Borycki AG (2018) Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal. Nat Commun 9:1075 CrossRef Google scholar

[12]	Sharif O, Bolshakov VN, Raines S, Newham P, Perkins ND (2007) Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol 8:1 CrossRef Google scholar

[13]	Stone RC, Pastar I, Ojeh N, Chen V, Liu S, Garzon KI, Tomic-Canic M (2016) Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res 365:495–506 CrossRef Google scholar

[14]	Wynn TA, Vannella KM (2016) Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44:450–462 CrossRef Google scholar

[15]	Zhang L, Huang G, Li X, Zhang Y, Jiang Y, Shen J, Liu J, Wang Q, Zhu J, Feng X (2013) Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1alpha in hepatocellular carcinoma. BMC Cancer 13:108 CrossRef Google scholar