Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Hanbo Li , Xiaoyu Wei , Li Zhou , Weiqi Zhang , Chen Wang , Yang Guo , Denghui Li , Jianyang Chen , Tianbin Liu , Yingying Zhang , Shuai Ma , Congyan Wang , Fujian Tan , Jiangshan Xu , Yang Liu , Yue Yuan , Liang Chen , Qiaoran Wang , Jing Qu , Yue Shen , Shanshan Liu , Guangyi Fan , Longqi Liu , Xin Liu , Yong Hou , Guang-Hui Liu , Ying Gu , Xun Xu

Protein Cell ›› 2021, Vol. 12 ›› Issue (1) : 57 -66.

PDF (4330KB)
Protein Cell ›› 2021, Vol. 12 ›› Issue (1) : 57 -66. DOI: 10.1007/s13238-020-00763-1
LETTER
LETTER

Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Author information +
History +
PDF (4330KB)

Cite this article

Download citation ▾
Hanbo Li, Xiaoyu Wei, Li Zhou, Weiqi Zhang, Chen Wang, Yang Guo, Denghui Li, Jianyang Chen, Tianbin Liu, Yingying Zhang, Shuai Ma, Congyan Wang, Fujian Tan, Jiangshan Xu, Yang Liu, Yue Yuan, Liang Chen, Qiaoran Wang, Jing Qu, Yue Shen, Shanshan Liu, Guangyi Fan, Longqi Liu, Xin Liu, Yong Hou, Guang-Hui Liu, Ying Gu, Xun Xu. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis. Protein Cell, 2021, 12(1): 57-66 DOI:10.1007/s13238-020-00763-1

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Doyle SL, O'Neill LA (2006) Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 72:1102–1113

[2]

Erickson JR, Gearhart MD, Honson DD, Reid TA, Gardner MK, Moriarity BS, Echeverri K (2016) A novel role for SALL4 during scar-free wound healing in axolotl. NPJ Regener Med 1:1–11

[3]

Forte E, Chimenti I, Rosa P, Angelini F, Pagano F, Calogero A, Giacomello A, Messina E (2017) EMT/MET at the crossroad of stemness, regeneration and oncogenesis: he Ying-Yang equilibrium recapitulated in cell spheroids. Cancers 9:98

[4]

Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, Gac-Santel M, Nowoshilow S, Kageyama J, Khattak (2018). Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science (New York, NY) 362

[5]

Godwin JW, Pinto AR, Rosenthal NA (2013) Macrophages are required for adult salamander limb regeneration. Proc Natl Acad Sci USA 110:9415–9420

[6]

Haas BJ, Whited JL (2017) Advances in decoding axolotl limb regeneration. Trends Genet 33:553–565

[7]

Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Investig 119:1420–1428

[8]

Leigh ND, Dunlap GS, Johnson K, Mariano R, Oshiro R, Wong AY, Bryant DM, Miller BM, Ratner A, Chen A (2018) Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution. Nat Commun 9:5153

[9]

Marwick JA, Mills R, Kay O, Michail K, Stephen J, Rossi AG, Dransfield I, Hirani N (2018) Neutrophils induce macrophage antiinflammatory reprogramming by suppressing NF-κB activation. Cell Death Dis 9:665

[10]

Meng XM, Nikolic-Paterson DJ, Lan HY (2016) TGF-beta: the master regulator of fibrosis. Nat Rev Nephrol 12:325–338

[11]

Rayagiri SS, Ranaldi D, Raven A, Mohamad Azhar NIF, Lefebvre O, Zammit PS, Borycki AG (2018) Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal. Nat Commun 9:1075

[12]

Sharif O, Bolshakov VN, Raines S, Newham P, Perkins ND (2007) Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol 8:1

[13]

Stone RC, Pastar I, Ojeh N, Chen V, Liu S, Garzon KI, Tomic-Canic M (2016) Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res 365:495–506

[14]

Wynn TA, Vannella KM (2016) Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44:450–462

[15]

Zhang L, Huang G, Li X, Zhang Y, Jiang Y, Shen J, Liu J, Wang Q, Zhu J, Feng X (2013) Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1alpha in hepatocellular carcinoma. BMC Cancer 13:108

RIGHTS & PERMISSIONS

The Author(s) 2020

AI Summary AI Mindmap
PDF (4330KB)

Supplementary files

PAC-0057-20351-GY_suppl_1

PAC-0057-20351-GY_suppl_2

1206

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/