FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice

Hongying Gao, Chunwei Zheng, Jian Du, Yue Wu, Yonghui Sun, Chunsheng Han, Kehkooi Kee, Yu Rao

Protein Cell ›› 2020, Vol. 11 ›› Issue (7) : 534-539.

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Protein Cell ›› 2020, Vol. 11 ›› Issue (7) : 534-539. DOI: 10.1007/s13238-020-00732-8
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FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice

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Hongying Gao, Chunwei Zheng, Jian Du, Yue Wu, Yonghui Sun, Chunsheng Han, Kehkooi Kee, Yu Rao. FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice. Protein Cell, 2020, 11(7): 534‒539 https://doi.org/10.1007/s13238-020-00732-8

References

[1]
Chaible LM, Corat MA, Abdelhay E, Dagli ML (2010) Genetically modified animals for use in research and biotechnology. Genet Mol Res 9:1469–1482
CrossRef Google scholar
[2]
Chan AW (2013) Progress and prospects for genetic modification of nonhuman primate models in biomedical research. ILAR J 54:211–223
CrossRef Google scholar
[3]
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA (2013) Multiplex genome engineering using CRISPR/Cas systems. Science 339:819–823
CrossRef Google scholar
[4]
Deng Y, Wang CC, Choy KW, Du Q, Chen J, Wang Q, Li L, Chung TK, Tang T (2014) Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies. Gene 538:217–227
CrossRef Google scholar
[5]
Dhanjal JK, Radhakrishnan N, Sundar D (2017) Identifying synthetic lethal targets using CRISPR/Cas9 system. Methods 131:66–73
CrossRef Google scholar
[6]
Doudna JA, Charpentier E (2014) Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346:1258096
CrossRef Google scholar
[7]
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494–498
CrossRef Google scholar
[8]
Gao H,Wu Y, Sun Y, Yang Y,Zhou G, Rao Y (2019) Design, synthesis, and evaluation of highly potentFAK-targetingPROTACs. ACSMed Chem Lett.https://doi.org/10.1021/acsmedchemlett.1029b00372
CrossRef Google scholar
[9]
Gungor-Ordueri NE, Mruk DD, Wan HT, Wong EW, Celik-Ozenci C, Lie PP, Cheng CY (2014) New insights into FAK function and regulation during spermatogenesis. Histol Histopathol 29:977–989
[10]
Hall JE, Fu W, Schaller MD (2011) Focal adhesion kinase: exploring Fak structure to gain insight into function. Int Rev Cell Mol Biol 288:185–225
CrossRef Google scholar
[11]
Raina K, Crews CM (2010) Chemical inducers of targeted protein degradation. J Biol Chem 285:11057–11060
CrossRef Google scholar
[12]
Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J (2008) Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res 68:1935–1944
CrossRef Google scholar
[13]
Schoch KM, Miller TM (2017) Antisense oligonucleotides: translation from mouse models to human neurodegenerative diseases. Neuron 94:1056–1070
CrossRef Google scholar
[14]
Siu ER, Wong EW, Mruk DD, Porto CS, Cheng CY (2009) Focal adhesion kinase is a blood-testis barrier regulator. Proc Natl Acad Sci USA 106:9298–9303
CrossRef Google scholar
[15]
Zheng C,Xing Z, Bian ZC, Guo C, Akbay A, Warner L, Guan JL (1998) Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion. J Biol Chem 273:2384–2389
CrossRef Google scholar

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