FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice
Hongying Gao, Chunwei Zheng, Jian Du, Yue Wu, Yonghui Sun, Chunsheng Han, Kehkooi Kee, Yu Rao
FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice
[1] |
Chaible LM, Corat MA, Abdelhay E, Dagli ML (2010) Genetically modified animals for use in research and biotechnology. Genet Mol Res 9:1469–1482
CrossRef
Google scholar
|
[2] |
Chan AW (2013) Progress and prospects for genetic modification of nonhuman primate models in biomedical research. ILAR J 54:211–223
CrossRef
Google scholar
|
[3] |
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA
CrossRef
Google scholar
|
[4] |
Deng Y, Wang CC, Choy KW, Du Q, Chen J, Wang Q, Li L, Chung TK, Tang T (2014) Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies. Gene 538:217–227
CrossRef
Google scholar
|
[5] |
Dhanjal JK, Radhakrishnan N, Sundar D (2017) Identifying synthetic lethal targets using CRISPR/Cas9 system. Methods 131:66–73
CrossRef
Google scholar
|
[6] |
Doudna JA, Charpentier E (2014) Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346:1258096
CrossRef
Google scholar
|
[7] |
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494–498
CrossRef
Google scholar
|
[8] |
Gao H,Wu Y, Sun Y, Yang Y,Zhou G, Rao Y (2019) Design, synthesis, and evaluation of highly potentFAK-targetingPROTACs. ACSMed Chem Lett.https://doi.org/10.1021/acsmedchemlett.1029b00372
CrossRef
Google scholar
|
[9] |
Gungor-Ordueri NE, Mruk DD, Wan HT, Wong EW, Celik-Ozenci C, Lie PP, Cheng CY (2014) New insights into FAK function and regulation during spermatogenesis. Histol Histopathol 29:977–989
|
[10] |
Hall JE, Fu W, Schaller MD (2011) Focal adhesion kinase: exploring Fak structure to gain insight into function. Int Rev Cell Mol Biol 288:185–225
CrossRef
Google scholar
|
[11] |
Raina K, Crews CM (2010) Chemical inducers of targeted protein degradation. J Biol Chem 285:11057–11060
CrossRef
Google scholar
|
[12] |
Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J
CrossRef
Google scholar
|
[13] |
Schoch KM, Miller TM (2017) Antisense oligonucleotides: translation from mouse models to human neurodegenerative diseases. Neuron 94:1056–1070
CrossRef
Google scholar
|
[14] |
Siu ER, Wong EW, Mruk DD, Porto CS, Cheng CY (2009) Focal adhesion kinase is a blood-testis barrier regulator. Proc Natl Acad Sci USA 106:9298–9303
CrossRef
Google scholar
|
[15] |
Zheng C,Xing Z, Bian ZC, Guo C, Akbay A, Warner L, Guan JL (1998) Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion. J Biol Chem 273:2384–2389
CrossRef
Google scholar
|
/
〈 | 〉 |