Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system

References

[1] Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K (2018) IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol 36:346–351

[2] Baeumler TA, Ahmed AA, Fulga TA (2017) Engineering synthetic signaling pathways with programmable dCas9-based chimeric receptors. Cell Rep 20:2639–2653

[3] He L, Huang J, Perrimon N (2017) Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor. Proc Natl Acad Sci U S A 114:5467–5472

[4] James AC, Szot JO, Iyer K, Major JA, Pursglove SE, Chapman G, Dunwoodie SL (2014) Notch4 reveals a novel mechanism regulating Notch signal transduction. Biochim Biophys Acta 1843:1272–1284

[5] Kipniss NH, Dingal P, Abbott TR, Gao Y, Wang H, Dominguez AA, Labanieh L, Qi LS (2017) Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system. Nat Commun 8:2212

[6] Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA (2016) Engineering customized cell sensing and response behaviors using synthetic Notch receptors. Cell 164:780–791

[7] Rosenberg SA (2014) IL-2: the first effective immunotherapy for human cancer. J Immunol 192:5451–5458

[8] Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA (2016a) Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. Cell 164:770–779

[9] Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA (2016b) Engineering Tcells with customized therapeutic response programs using synthetic Notch receptors. Cell 167(419–432):e416

[10] Sakamoto K, Chao WS, Katsube K, Yamaguchi A (2005) Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res 302:281–291

[11] Schwarz KA, Daringer NM, Dolberg TB, Leonard JN (2017) Rewiring human cellular input-output using modular extracellular sensors. Nat Chem Biol 13:202–209

[12] Shao J, Wang M, Yu G, Zhu S, Yu Y, Heng BC, Wu J, Ye H (2018) Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Proc Natl Acad Sci USA 115:E6722–E6730

[13] Suzuki K, Tsunekawa Y, Hernandezbenitez R, Wu J, Jie Z, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Zhe L (2016) In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature 540:144–149

[14] Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL et al (2013) Engineered SIRPalpha variants as immunotherapeutic adjuvants to anticancer antibodies. Science 341:88–91

[15] Zetsche B, Volz SE, Zhang F (2015) A split-Cas9 architecture for inducible genome editing and transcription modulation. Nat Biotechnol 33:139–142

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