LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons

References

[1] Birey F, Andersen J,Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KR, Panagiotakos G, Thom N (2017) Assembly of functionally integrated human forebrain spheroids. Nature 545:54

[2] Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI (2012) Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injuryinduced neuropathic pain. Neuron 74(4):663–675

[3] Butt SJ, Fuccillo M, Nery S, Noctor S, Kriegstein A, Corbin JG, Fishell G (2005) The temporal and spatial origins of cortical interneurons predict their physiological subtype. Neuron 48 (4):591–604

[4] Chen Y,Cao J, Xiong M, Petersen AJ, Dong Y, Tao Y, Zhang SC (2015) Engineering human stem cell lines with inducible gene knockout using CRISPR/Cas9. Cell Stem Cell 17(2):233–244

[5] Cunningham M, Cho JH, Leung A, Savvidis G,Ahn S, Moon M, Lee PK, Han JJ, Azimi N, Kim KS (2014) hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15(5):559–573

[6] Flandin P, Zhao Y, Vogt D, Jeong J, Long J, Potter G,Westphal H, Rubenstein JL (2011) Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron 70(5):939–950

[7] Kuzirian MS, Moore AR, Staudenmaier EK, Friedel RH, Paradis S (2013) The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. J Neurosci 33(21):8961–8973

[8] Liodis P, Denaxa M, Grigoriou M, Akufo-Addo C, Yanagawa Y, Pachnis V (2007) Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27(12):3078–3089

[9] Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H (2004) Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. Embo J 23(5):1075–1088

[10] Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T,Yang Z, Baraban SC, Rubenstein JL (2014) Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron 82(2):350–364

[11] Yang WZ, Liu TT, Cao JW, Chen XF, Liu X, Wang M, Su X, Zhang SQ, Qiu BL, Hu WX (2016) Fear erasure facilitated by immature inhibitory neuron transplantation. Neuron 92(6):1352–1367

[12] Yuan F, Chen X, Fang KH, Wang Y, Lin M, Xu SB, Huo HQ, Xu M, Ma L, Chen Y (2018) Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6. eLife 7:e37382

[13] Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M (2009) SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron 64(2):173–187

[14] Zhao Y,Flandin P, Long JE, Cuesta MD, Westphal H,Rubenstein JLR (2008) Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol 510(1):79–99

RIGHTS & PERMISSIONS

The Author(s)