Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation

Jianxi Zhu , Mingyang Xu , Yi Liu , Lisha Zhuang , Kejun Ying , Feng Liu , Dan Liu , Wenbin Ma , Zhou Songyang

Protein Cell ›› 2019, Vol. 10 ›› Issue (5) : 382 -387.

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Protein Cell ›› 2019, Vol. 10 ›› Issue (5) : 382 -387. DOI: 10.1007/s13238-018-0593-9
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Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation

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Jianxi Zhu, Mingyang Xu, Yi Liu, Lisha Zhuang, Kejun Ying, Feng Liu, Dan Liu, Wenbin Ma, Zhou Songyang. Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation. Protein Cell, 2019, 10(5): 382-387 DOI:10.1007/s13238-018-0593-9

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References

[1]

Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Honing S (2009) TIP47 functions in the biogenesis of lipid droplets. J Cell Biol 185:641–655

[2]

Carling D, Aguan K, Woods A, Verhoeven AJ, Beri RK, Brennan CH, Sidebottom C, Davison MD, Scott J (1994) Mammalian AMPactivated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. J Biol Chem 269:11442–11448

[3]

Dyck JR, Kudo N, Barr AJ, Davies SP, Hardie DG, Lopaschuk GD (1999) Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5’-AMP activated protein kinase. Eur J Biochem 262:184–190

[4]

Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL (2013) AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol 305:F679–690

[5]

Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Ruperez C, Fernandez-Vidal A, Ferguson C, Rentero C, Tebar F (2015) AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun 6:7176

[6]

Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH (2004) Structure of a lipid droplet protein; the PAT family member TIP47. Structure 12:1199–1207

[7]

Hocsak E, Racz B, Szabo A, Mester L, Rapolti E, Pozsgai E, Javor S, Bellyei S, Gallyas F Jr, Sumegi B (2010) TIP47 protects mitochondrial membrane integrity and inhibits oxidative-stressinduced cell death. FEBS Lett 584:2953–2960

[8]

Kaushik S, Cuervo AM (2016) AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy 12:432–438

[9]

Kuo T, Chen TC, Lee RA, Nguyen NHT, Broughton AE, Zhang D, Wang JC (2017) Pik3r1 is required for glucocorticoid-induced perilipin 1 phosphorylation in lipid droplet for adipocyte lipolysis. Diabetes 66:1601–1610

[10]

Levin K, Daa Schroeder H, Alford FP, Beck-Nielsen H (2001) Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with type II diabetes. Diabetologia 44:824–833

[11]

Louche K, Badin PM, Montastier E, Laurens C, Bourlier V, de Glisezinski I, Thalamas C, Viguerie N, Langin D, Moro C (2013) Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects. J Clin Endocrinol Metab 98:4863–4871

[12]

Ohsaki Y, Cheng J, Fujita A, Tokumoto T, Fujimoto T (2006) Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. Mol Biol Cell 17:2674–2683

[13]

Patel S, Yang W, Kozusko K, Saudek V, Savage DB (2014) Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis. Proc Natl Acad Sci USA 111:9163–9168

[14]

Sanders MA, Madoux F, Mladenovic L, Zhang H, Ye X, Angrish M, Mottillo EP, Caruso JA, Halvorsen G, Roush WR (2015) Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle. Cell Metab 22:851–860

[15]

Storey SM, McIntosh AL, Senthivinayagam S, Moon KC, Atshaves BP (2011) The phospholipid monolayer associated with perilipinenriched lipid droplets is a highly organized rigid membrane structure. Am J Physiol 301:E991–E1003

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