Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo

References

[1] Baize S, Leroy EM, Georges AJ (2002) Inflammatory responses in Ebola virus-infected patients. Clin Exp Immunol 128:163–168

[2] Chan SY, Ma MC, Goldsmith MA (2000) Differential induction of cellular detachment by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. J Gen Virol 81:2155–2159

[3] Cilloniz C, Ebihara H, Ni C (2011) Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection. J Virol 85:9060–9068

[4] Feldmann H, Geisbert TW (2011) Ebola haemorrhagic fever. Lancet 377:849–862

[5] Francica JR, Matukonis MK, Bates P (2009) Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein. Virology 383:237–247

[6] He TC, Zhou SB, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509–2514

[7] Jeffers SA, Sanders DA, Sanchez A (2002) Covalent modifications of the ebola virus glycoprotein. J Virol 76:12463–12472

[8] Ning YJ, Deng F, Hu ZH, Wang HL (2017) The roles of ebolavirus glycoproteins in viral pathogenesis. Virol Sin 32:3–15

[9] Ohimain EI (2016) Recent advances in the development of vaccines for Ebola virus disease. Virus Res 211:174–185

[10] Simmons G, Wool-Lewis RJ, Baribaud F, Netter RC, Bates P (2002) Ebola virus glycoproteins induce global surface protein downmodulation and loss of cell adherence. J Virol 76:2518–2528

[11] Singh G, Kumar A, Singh K, Kaur J (2015) Ebola virus: an introduction and its pathology. Rev Med Virol 26(1):49–56

[12] Takada A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y (2000) Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry. Virology 278:20–26

[13] Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ (2000) Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nat Med 6:886–889

[14] Zaki SR, Shieh WJ, Greer PW (1999) A novel immunohistochemical assay for the detection of Ebola virus in skin: Implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. J Infect Dis 179:S36–S47

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The Author(s) 2017. This article is an open access publication