Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo

Yun-Jia Ning, Zhenyu Kang, Jingjun Xing, Yuan-Qin Min, Dan Liu, Kuan Feng, Manli Wang, Fei Deng, Yiwu Zhou, Zhihong Hu, Hualin Wang

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Protein Cell ›› 2018, Vol. 9 ›› Issue (4) : 389-393. DOI: 10.1007/s13238-017-0471-x
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Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo

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Yun-Jia Ning, Zhenyu Kang, Jingjun Xing, Yuan-Qin Min, Dan Liu, Kuan Feng, Manli Wang, Fei Deng, Yiwu Zhou, Zhihong Hu, Hualin Wang. Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo. Protein Cell, 2018, 9(4): 389‒393 https://doi.org/10.1007/s13238-017-0471-x

References

[1]
Baize S, Leroy EM, Georges AJ (2002) Inflammatory responses in Ebola virus-infected patients. Clin Exp Immunol 128:163–168
CrossRef Google scholar
[2]
Chan SY, Ma MC, Goldsmith MA (2000) Differential induction of cellular detachment by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. J Gen Virol 81:2155–2159
CrossRef Google scholar
[3]
Cilloniz C, Ebihara H, Ni C (2011) Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection. J Virol 85:9060–9068
CrossRef Google scholar
[4]
Feldmann H, Geisbert TW (2011) Ebola haemorrhagic fever. Lancet 377:849–862
CrossRef Google scholar
[5]
Francica JR, Matukonis MK, Bates P (2009) Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein. Virology 383:237–247
CrossRef Google scholar
[6]
He TC, Zhou SB, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509–2514
CrossRef Google scholar
[7]
Jeffers SA, Sanders DA, Sanchez A (2002) Covalent modifications of the ebola virus glycoprotein. J Virol 76:12463–12472
CrossRef Google scholar
[8]
Ning YJ, Deng F, Hu ZH, Wang HL (2017) The roles of ebolavirus glycoproteins in viral pathogenesis. Virol Sin 32:3–15
CrossRef Google scholar
[9]
Ohimain EI (2016) Recent advances in the development of vaccines for Ebola virus disease. Virus Res 211:174–185
CrossRef Google scholar
[10]
Simmons G, Wool-Lewis RJ, Baribaud F, Netter RC, Bates P (2002) Ebola virus glycoproteins induce global surface protein downmodulation and loss of cell adherence. J Virol 76:2518–2528
CrossRef Google scholar
[11]
Singh G, Kumar A, Singh K, Kaur J (2015) Ebola virus: an introduction and its pathology. Rev Med Virol 26(1):49–56
CrossRef Google scholar
[12]
Takada A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y (2000) Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry. Virology 278:20–26
CrossRef Google scholar
[13]
Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ (2000) Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nat Med 6:886–889
CrossRef Google scholar
[14]
Zaki SR, Shieh WJ, Greer PW (1999) A novel immunohistochemical assay for the detection of Ebola virus in skin: Implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. J Infect Dis 179:S36–S47
CrossRef Google scholar

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