Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC

References

[1] AhmedG, ShinmyoY, OhtaK, IslamSM, HossainM, NaserIB, RiyadhMA, SuY, ZhangS, Tessier-LavigneM (2011) Draxin inhibits axonal outgrowth through the netrin receptor DCC.J Neurosci31:14018–14023

[2] BushellKM, SollnerC, Schuster-BoecklerB, BatemanA, WrightGJ (2008) Large-scale screening for novel low-affinity extracellular protein interactions.Genome Res18:622–630

[3] CooperHM, ArmesP, BrittoJ, GadJ, WilksAF (1995) Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo.Oncogene11:2243–2254

[4] FearonER, ChoKR, NigroJM, KernSE, SimonsJW, RuppertJM, HamiltonSR, PreisingerAC, ThomasG, KinzlerKW (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers.Science247:49–56

[5] FinciLI, KrugerN, SunX, ZhangJ, ChegkaziM, WuY, SchenkG, MertensHD, SvergunDI, ZhangY (2014) The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue.Neuron83:839–849

[6] FinciL, ZhangY, MeijersR, WangJ-H (2015) Signaling mechanism of the netrin-1 receptor DCC in axon guidance.Prog Biophys Mol Biol118:153–160

[7] GaoX, MetzgerU, PanzaP, MahalwarP, AlsheimerS, GeigerH, MaischeinHM, LevesqueMP, TemplinM, SollnerC (2015) A floor-plate extracellular protein-protein interaction screen identifies draxin as a secreted netrin-1 antagonist.Cell Rep12:694–708

[8] HongK, HinckL, NishiyamaM, PooMM, Tessier-LavigneM, SteinE (1999) A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.Cell97:927–941

[9] JaninJ (1997) Specific versus non-specific contacts in protein crystals.Nat Struct Biol4:973–974

[10] KennedyTE, SerafiniT, de la TorreJR, Tessier-LavigneM (1994) Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.Cell78:425–435

[11] LeggereJC, SaitoY, DarnellRB, Tessier-LavigneM, JungeHJ, ChenZ (2016) NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.eLife 5, e14264

[12] RounsevellRW, ClarkeJ (2004) FnIII domains: predicting mechanical stability.Structure12:4–5

[13] VakonakisI, StauntonD, RooneyLM, CampbellID (2007) Interdomain association in fibronectin: insight into cryptic sites and fibrillogenesis.EMBO J26:2575–2583

[14] XuK, WuZ, RenierN, AntipenkoA, Tzvetkova-RobevD, XuY, MinchenkoM, Nardi-DeiV, RajashankarKR, HimanenJ (2014) Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.Science344:1275–1279

RIGHTS & PERMISSIONS

The Author(s) 2017. This article is an open access publication