Screening novel stress granule regulators from a natural compound library

References

[1] AndersonP, KedershaN (2006) RNA granules. J Cell Biol172:803–808

[2] AndersonP, KedershaN (2009) RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol10:430–436

[3] AndersonP, KedershaN, IvanovP (2015) Stress granules, P-bodies and cancer. Biochim Biophys Acta1849:861–870

[4] JainS, WheelerJR, WaltersRW, AgrawalA, BarsicA, ParkerR (2016) ATPase-modulated stress granules contain a diverse proteome and substructure. Cell164:487–498

[5] KatoM, HanTW, XieS, ShiK, DuX, WuLC, MirzaeiH, GoldsmithEJ, LonggoodJ, PeiJ (2012) Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell149:753–767

[6] KedershaNL, GuptaM, LiW, MillerI, AndersonP (1999) RNAbinding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol147:1431–1442

[7] LiYR, KingOD, ShorterJ, GitlerAD (2013) Stress granules as crucibles of ALS pathogenesis. J Cell Biol201:361–372

[8] MahboubiH, StochajU (2017) Cytoplasmic stress granules: dynamic modulators of cell signaling and disease. Biochim Biophys Acta1863:884–895

[9] PanasMD, IvanovP, AndersonP (2016) Mechanistic insights into mammalian stress granule dynamics. J Cell Biol215:313–323

[10] PatelA, LeeHO, JawerthL, MaharanaS, JahnelM, HeinMY, StoynovS, MahamidJ, SahaS, FranzmannTM (2015) A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation. Cell162:1066–1077

[11] ProtterDS, ParkerR (2016) Principles and properties of stress granules. Trends Cell Biol26:668–679

[12] ReijnsMA, AlexanderRD, SpillerMP, BeggsJD (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci121:2463–2472

[13] StoecklinG, StubbsT, KedershaN, WaxS, RigbyWF, BlackwellTK, AndersonP (2004) MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J23:1313–1324

[14] TourriereH, ChebliK, ZekriL, CourselaudB, BlanchardJM, BertrandE, TaziJ (2003) The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol160:823–831

[15] WilczynskaA, AigueperseC, KressM, DautryF, WeilD (2005) The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules. J Cell Sci118:981–992

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