N4 DNA recognition by STAT6: structural and functional implications

Xiang Zhou, Zhengfan Jiang

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PDF(309 KB)
Protein Cell ›› 2017, Vol. 8 ›› Issue (4) : 240-241. DOI: 10.1007/s13238-017-0380-z
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N4 DNA recognition by STAT6: structural and functional implications

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Xiang Zhou, Zhengfan Jiang. N4 DNA recognition by STAT6: structural and functional implications. Protein Cell, 2017, 8(4): 240‒241 https://doi.org/10.1007/s13238-017-0380-z

References

[1]
ChenH, JiangZ (2013) The essential adaptors of innate immune signaling. Protein Cell4:27–39
CrossRef Google scholar
[2]
ChenH, SunH, YouF, SunW, ZhouX, ChenL, YangJ, WangY, TangH, GuanY (2011) Activation of STAT6 by STING is critical for antiviral innate immunity. Cell147:436–446
CrossRef Google scholar
[3]
JiangY, ZhuY, LiuZJ, OuyangS (2016) The emerging roles of the DDX41 protein in immunity and diseases. Protein Cell8:83–89
CrossRef Google scholar
[4]
LiJ, RodriguezJP, NiuF,PuM, WangJ, HungLW, ShaoQ, ZhuY, DingW, LiuY (2016) Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci USA113:13015–13020
CrossRef Google scholar
[5]
MaZ, DamaniaB (2016) The cGAS-STING defense pathway and its counteraction by viruses. Cell Host Microbe19:150–158
CrossRef Google scholar
[6]
NiX, RuH, MaF, ZhaoL, ShawN, FengY, DingW, GongW, WangQ, OuyangS (2016) New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16. J Mol Cell Biol8:51–61
CrossRef Google scholar
[7]
OuyangS, SongX, WangY, RuH, ShawN, JiangY, NiuF, ZhuY, QiuW, ParvatiyarK (2012) Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity36:1073–1086
CrossRef Google scholar
[8]
ParvatiyarK, ZhangZ, TelesRM, OuyangS, JiangY, IyerSS, ZaverSA, SchenkM, ZengS, ZhongW (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol13:1155–1161
CrossRef Google scholar
[9]
RuH, NiX, ZhaoL, CrowleyC, DingW, HungLW, ShawN, ChengG, LiuZJ (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Res23:855–858
CrossRef Google scholar
[10]
ShawN, OuyangS, LiuZJ (2013) Binding of bacterial secondary messenger molecule c di-GMP is a STING operation. Protein Cell4:117–129
CrossRef Google scholar
[11]
TakeuchiO, AkiraS (2010) Pattern recognition receptors and inflammation. Cell140:805–820
CrossRef Google scholar
[12]
ZhangL, MoJ, SwansonKV, WenH, PetrucelliA, GregorySM, ZhangZ, SchneiderM, JiangY, FitzgeraldKA (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity40:329–341
CrossRef Google scholar
[13]
ZhaoL, HuaT, CrowleyC, RuH, NiX, ShawN, JiaoL, DingW, QuL, HungLW (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res24:344–358
CrossRef Google scholar

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2017 The Author(s) 2017. This article is published with open access at Springerlink.com and journal.hep.com.cn
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