Overexpression of Hdac6 extends reproductive lifespan in mice

Xiaoxi Zhang, Jiao Yang, Haiying Wang, Renpeng Guo, Yu Yin, Dongdong Zhang, Qian Zhang, Hua Wang, Zhongcheng Zhou, Lingyi Chen, Jun Zhou, Lin Liu

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Protein Cell ›› 2017, Vol. 8 ›› Issue (5) : 360-364. DOI: 10.1007/s13238-017-0375-9
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Overexpression of Hdac6 extends reproductive lifespan in mice

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Xiaoxi Zhang, Jiao Yang, Haiying Wang, Renpeng Guo, Yu Yin, Dongdong Zhang, Qian Zhang, Hua Wang, Zhongcheng Zhou, Lingyi Chen, Jun Zhou, Lin Liu. Overexpression of Hdac6 extends reproductive lifespan in mice. Protein Cell, 2017, 8(5): 360‒364 https://doi.org/10.1007/s13238-017-0375-9

References

[1]
HubbertC, GuardiolaA, ShaoR, KawaguchiY, ItoA, NixonA, YoshidaM, WangXF, YaoTP (2002) HDAC6 is a microtubuleassociated deacetylase.Nature417:455–458
CrossRef Google scholar
[2]
LeeYS, LimKH, GuoX, KawaguchiY, GaoY, BarrientosT, OrdentlichP, WangXF, CounterCM, YaoTP (2008) The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.Cancer Res68:7561–7569
CrossRef Google scholar
[3]
LeeJY, KogaH, KawaguchiY, TangW, WongE, GaoYS, PandeyUB, KaushikS, TresseE, LuJ (2010) HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.EMBO J29:969–980
CrossRef Google scholar
[4]
LiuL (2017) Linking telomere regulation to stem cell pluripotency.Trends Genet33:16–33
CrossRef Google scholar
[5]
MaynardS, FangEF, Scheibye-KnudsenM, CroteauDL, BohrVA (2015) DNA damage, DNA repair, aging, and neurodegeneration.Cold Spring Harb Perspect Med.
CrossRef Google scholar
[6]
NamdarM, PerezG, NgoL, MarksPA (2010) Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.Proc Natl Acad Sci USA107:20003–20008
CrossRef Google scholar
[7]
PandeyUB, NieZ, BatleviY, McCrayBA, RitsonGP, NedelskyNB, SchwartzSL, DiProsperoNA, KnightMA, SchuldinerO (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.Nature447:859–863
CrossRef Google scholar
[8]
Seigneurin-BernyD, VerdelA, CurtetS, LemercierC, GarinJ, RousseauxS, KhochbinS (2001) Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.Mol Cell Biol21:8035–8044
CrossRef Google scholar
[9]
TitusS, LiF, StobezkiR, AkulaK, UnsalE, JeongK, RobsonM, RobsonF, MoyF, GoswamiS (2013) Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.Sci Transl Med5:172ra121
CrossRef Google scholar
[10]
Valenzuela-FernandezA, CabreroJR, SerradorJM, Sanchez-MadridF (2008) HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions.Trends Cell Biol18:291–297
CrossRef Google scholar
[11]
VarelaE, Munoz-LorenteMA, TejeraAM, OrtegaS, BlascoMA (2016) Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations.Nat Commun7:11739
CrossRef Google scholar
[12]
VasilevaA, HopkinsKM, WangX, WeisbachMM, FriedmanRA, WolgemuthDJ, LiebermanHB (2013) The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse.J Cell Sci126:3927–3938
CrossRef Google scholar
[13]
WangD, MengQ, HuoL, YangM, WangL, ChenX, WangJ, LiZ, YeX, LiuN (2015) Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice.Protein Cell6:152–156
CrossRef Google scholar
[14]
ZhangY, KwonS, YamaguchiT, CubizollesF, RousseauxS, KneisselM, CaoC, LiN, ChengHL, ChuaK (2008) Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.Mol Cell Biol28:1688–1701
CrossRef Google scholar
[15]
ZhangM, XiangS, JooHY, WangL, WilliamsKA, LiuW, HuC, TongD, HaakensonJ, WangC (2014) HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSalpha.Mol Cell55:31–46
CrossRef Google scholar

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2017 The Author(s) 2017. This article is published with open access at Springerlink.com and journal.hep.com.cn
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