Overexpression of Hdac6 extends reproductive lifespan in mice

References

[1] HubbertC, GuardiolaA, ShaoR, KawaguchiY, ItoA, NixonA, YoshidaM, WangXF, YaoTP (2002) HDAC6 is a microtubuleassociated deacetylase.Nature417:455–458

[2] LeeYS, LimKH, GuoX, KawaguchiY, GaoY, BarrientosT, OrdentlichP, WangXF, CounterCM, YaoTP (2008) The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.Cancer Res68:7561–7569

[3] LeeJY, KogaH, KawaguchiY, TangW, WongE, GaoYS, PandeyUB, KaushikS, TresseE, LuJ (2010) HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.EMBO J29:969–980

[4] LiuL (2017) Linking telomere regulation to stem cell pluripotency.Trends Genet33:16–33

[5] MaynardS, FangEF, Scheibye-KnudsenM, CroteauDL, BohrVA (2015) DNA damage, DNA repair, aging, and neurodegeneration.Cold Spring Harb Perspect Med.

[6] NamdarM, PerezG, NgoL, MarksPA (2010) Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.Proc Natl Acad Sci USA107:20003–20008

[7] PandeyUB, NieZ, BatleviY, McCrayBA, RitsonGP, NedelskyNB, SchwartzSL, DiProsperoNA, KnightMA, SchuldinerO (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.Nature447:859–863

[8] Seigneurin-BernyD, VerdelA, CurtetS, LemercierC, GarinJ, RousseauxS, KhochbinS (2001) Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.Mol Cell Biol21:8035–8044

[9] TitusS, LiF, StobezkiR, AkulaK, UnsalE, JeongK, RobsonM, RobsonF, MoyF, GoswamiS (2013) Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.Sci Transl Med5:172ra121

[10] Valenzuela-FernandezA, CabreroJR, SerradorJM, Sanchez-MadridF (2008) HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions.Trends Cell Biol18:291–297

[11] VarelaE, Munoz-LorenteMA, TejeraAM, OrtegaS, BlascoMA (2016) Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations.Nat Commun7:11739

[12] VasilevaA, HopkinsKM, WangX, WeisbachMM, FriedmanRA, WolgemuthDJ, LiebermanHB (2013) The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse.J Cell Sci126:3927–3938

[13] WangD, MengQ, HuoL, YangM, WangL, ChenX, WangJ, LiZ, YeX, LiuN (2015) Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice.Protein Cell6:152–156

[14] ZhangY, KwonS, YamaguchiT, CubizollesF, RousseauxS, KneisselM, CaoC, LiN, ChengHL, ChuaK (2008) Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.Mol Cell Biol28:1688–1701

[15] ZhangM, XiangS, JooHY, WangL, WilliamsKA, LiuW, HuC, TongD, HaakensonJ, WangC (2014) HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSalpha.Mol Cell55:31–46

RIGHTS & PERMISSIONS

The Author(s) 2017. This article is published with open access at Springerlink.com and journal.hep.com.cn