3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection

Song Wang; Xiaoqin Luo; Ruoxiang Yan; Quanxin Wang; Qiuyue Qi; Xiaojuan Chi; Lanlan Zhang; Ziding Yu; Binxiang Cai; Ji-Long Chen; Hongwei Liu

doi:10.1007/s13238-016-0325-y

Protein Cell ›› 2016, Vol. 7 ›› Issue (11) : 839 -843. DOI: 10.1007/s13238-016-0325-y

LETTER

3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection

Author information +

History +

PDF (570KB)

Cite this article

Download citation ▾

Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, Ziding Yu, Binxiang Cai, Ji-Long Chen, Hongwei Liu. 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein Cell, 2016, 7(11): 839-843 DOI:10.1007/s13238-016-0325-y

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Au TK, Chick WS, Leung PC (2000) The biology of ophiobolins. Life Sci 67:733–742

[2]	Cheng PK, Leung TW, Ho EC, Leung PC, Ng AY, Lai MY, Lim WW (2009) Oseltamivir-and amantadine-resistant influenza viruses A (H1N1). Emerg Infect Dis 15:966

[3]	Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T (2012) Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. J Biol Chem 287:35324–35332

[4]	Droebner K, Pleschka S, Ludwig S, Planz O (2011) Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res 92:195–203

[5]	Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K (2013) Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368:1888–1897

[6]	Haasbach E, Reiling SJ, Ehrhardt C, Droebner K, Ruckle A, Hrincius ER, Leban J, Strobl S, Vitt D, Ludwig S (2013) The NFkappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res 99:336–344

[7]	Hurt AC, Holien JK, Parker M, Kelso A, Barr IG (2009) Zanamivirresistant influenza viruses with a novel neuraminidase mutation. J Virol 83:10366–10373

[8]	Karlas A, Machuy N, Shin Y, Pleissner KP, Artarini A, Heuer D, Becker D, Khalil H, Ogilvie LA, Hess S (2010) Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature. 463:818–822

[9]	Moscona A (2009) Global transmission of oseltamivir-resistant influenza. N Engl J Med 360:953–956

[10]	Phuwapraisirisan P, Sawang K, Siripong P, Tip-Pyang S (2007) Anhydrocochlioquinone A, a new antitumor compound from Bipolaris oryzae. Tetrahedron Lett. 48:5193–5195

[11]	Planz O (2013) Development of cellular signaling pathway inhibitors as new antivirals against influenza. Antiviral Res 98:457–468

[12]	Regoes RR, Bonhoeffer S (2006) Emergence of drug-resistant influenza virus: population dynamical considerations. Science 312:389–391

[13]

Wang QX, Yang JL, Qi QY, Bao L, Yang XL, Liu MM, Huang P, Zhang LX, Chen JL, Cai L (2013) 3-Anhydro-6-hydroxyophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorg Med Chem Lett 23:3547–3550

[14]	Watanabe T, Watanabe S, Kawaoka Y (2010) Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 7:427–439

[15]	Yang T, Lu Z, Meng L, Wei S, Hong K, Zhu W, Huang C (2012) The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. Bioorg Med Chem Lett 22:579–585