The PilZ domain of MrkH represents a novel DNA binding motif

References

[1] Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A (2007) The structural basis of cyclic diguanylate signal transduction by PilZ domains. Embo J 26:5153–5166

[2] Christen M, Christen B, Allan MG, Folcher M, Jeno P, Grzesiek S, Jenal U (2007) DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in caulobacter crescentus. Proc Natl Acad Sci USA 104:7729

[3] Holm L, Rosenstrom P (2010) Dali server: conservation mapping in 3D. Nucleic Acids Res 38:W545–W549

[4] Johnson JG, Murphy CN, Sippy J, Johnson TJ, Clegg S (2011) Type 3 fimbriae and biofilm formation are regulated by the transcriptional regulators MrkHI in Klebsiella pneumoniae. J Bacteriol 193:3453–3460

[5] Ko J, Ryu KS, Kim H, Shin JS, Lee JO, Cheong C, Choi BS (2010) Structure of PP4397 reveals the molecular basis for different c-di-GMP binding modes by Pilz domain proteins. J Mol Biol 398:97–110

[6] Murphy CN, Clegg S (2012) Klebsiella pneumoniae and type 3 fimbriae: nosocomial infection, regulation and biofilm formation. Futur Microbiol 7:1234

[7] Ryan RP, Tolker-Nielsen T, Dow JM (2012) When the PilZ don't work: effectors for cyclic di-GMP action in bacteria. Trends Microbiol 20:235–242

[8] Stivala A, Wybrow M, Wirth A, Whisstock JC, Stuckey PJ (2011) Automatic generation of protein structure cartoons with Proorigami. Bioinformatics 27:3315–3316

[9] Tan JWH, Wilksch JJ, Hocking DM, Wang N, Srikhanta YN, Tauschek M, Lithgow T, Robins-Browne RM, Yang J, Strugnell RA (2015) Positive autoregulation of mrkHI by the cyclic Di-GMPdependent MrkH protein in the biofilm regulatory circuit of Klebsiella pneumoniae. J Bacteriol 197:1659–1667

[10] Tuszynska I, Magnus M, Jonak K, Dawson W, Bujnicki JM (2015) NPDock: a web server for protein–nucleic acid docking. Nucleic Acids Res 43(W1):W425–W430

[11] Whitney JC, Whitfield GB, Marmont LS, Yip P, Neculai AM, Lobsanov YD, Robinson H, Ohman DE, Howell PL (2015) Dimeric c-di-GMP is required for post-translational regulation of alginate production in pseudomonas aeruginosa. J Biol Chem 290:12451–12462

[12] Wilksch JJ, Yang J, Clements A, Gabbe JL, Short KR, Cao H, Cavaliere R, James CE, Whitchurch CB, Schembri MA (2011) MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression. PLoS Pathog 7:e1002204

[13] Yang J, Wilksch JJ, Tan JW, Hocking DM, Webb CT, Lithgow T, Robins-Browne RM, Strugnell RA (2013) Transcriptional activation of the mrkA promoter of the Klebsiella pneumoniae type 3 fimbrial operon by the c-di-GMP-dependent MrkH protein. PLoS One 8:e79038

RIGHTS & PERMISSIONS

The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn