Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach

Yuwei Bai, Shinya Tashiro, Satoru Nagatoishi, Toru Suzuki, Dongke Yan, Ruihua Liu, Kouhei Tsumoto, Mark Bartlam

PDF(918 KB)
PDF(918 KB)
Protein Cell ›› 2015, Vol. 06 ›› Issue (12) : 924-928. DOI: 10.1007/s13238-015-0225-6
LETTER
LETTER

Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach

Author information +
History +

Cite this article

Download citation ▾
Yuwei Bai, Shinya Tashiro, Satoru Nagatoishi, Toru Suzuki, Dongke Yan, Ruihua Liu, Kouhei Tsumoto, Mark Bartlam. Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach. Protein Cell, 2015, 06(12): 924‒928 https://doi.org/10.1007/s13238-015-0225-6

References

[1]
Doidge R, Mittal S, Aslam A, Winkler GS (2012) The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PLoS One 7:e51331
[2]
Ezzeddine N, Chang TC, Zhu W, Yamashita A, Chen CY, Zhong Z, Yamashita Y, Zheng D, Shyu AB (2007) Human TOB, an antiproliferative transcription factor, is a poly(A)-binding proteindependent positive regulator of cytoplasmic mRNA deadenylation. Mol Cell Biol 27:7791–7801
CrossRef Google scholar
[3]
Ezzeddine N, Chen CY, Shyu AB (2012) Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. Mol Cell Biol 32:1089–1098
CrossRef Google scholar
[4]
Giannetti AM, Koch BD, Browner MF (2008) Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors. J Med Chem 51:574–580
CrossRef Google scholar
[5]
Hann MM, Leach AR, Harper G (2001) Molecular complexity and its impact on the probability of finding leads for drug discovery. J Chem Inf Comput Sci 41:856–864
CrossRef Google scholar
[6]
Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F (2009) Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. J Biol Chem 284:13244–13255
CrossRef Google scholar
[7]
Ito Y, Suzuki T, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K (2005) Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroid. Cancer Lett 220:237–242
CrossRef Google scholar
[8]
Iwanaga K, Sueoka N, Sato A, Sakuragi T, Sakao Y, Tominaga M, Suzuki T, Yoshida Y, Tsuzuku KT, Yamamoto T (2003) Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. Cancer Lett 202:71–79
CrossRef Google scholar
[9]
Jia S, Meng A (2007) Tob genes in development and homeostasis. Dev Dyn 236:913–921
CrossRef Google scholar
[10]
Matsuda S, Rouault J, Magaud J, Berthet C (2001) In search of a function for the TIS21/PC3/BTG1/TOB family. FEBS Lett 497:67–72
CrossRef Google scholar
[11]
Mauxion F, Chen CY, Seraphin B, Shyu AB (2009) BTG/TOB factors impact deadenylases. Trends Biochem Sci 34:640–647
CrossRef Google scholar
[12]
Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR (2015) Biophysical methods for identifying fragment-based inhibitors of proteinprotein interactions. Methods Mol Biol 1278:587–613
CrossRef Google scholar
[13]
Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H (2012) Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob. J Biol Chem 287:40256–40265
CrossRef Google scholar
[14]
Winkler GS (2010) The mammalian anti-proliferative BTG/Tob protein family. J Cell Physiol 222:66–72
CrossRef Google scholar
[15]
Yang X, Morita M, Wang H, Suzuki T, Yang W, Luo Y, Zhao C, Yu Y, Bartlam M, Yamamoto T (2008) Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1deadenylase activity. Nucleic Acids Res 36:6872–6881
CrossRef Google scholar

RIGHTS & PERMISSIONS

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
AI Summary AI Mindmap
PDF(918 KB)

Accesses

Citations

Detail

Sections
Recommended

/