Three-dimensional regulation of transcription

Jun Cao, Zhengyu Luo, Qingyu Cheng, Qianlan Xu, Yan Zhang, Fei Wang, Yan Wu, Xiaoyuan Song

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Protein Cell ›› 2015, Vol. 6 ›› Issue (4) : 241-253. DOI: 10.1007/s13238-015-0135-7
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Three-dimensional regulation of transcription

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Abstract

Cells can adapt to environment and development by reconstructing their transcriptional networks to regulate diverse cellular processes without altering the underlying DNA sequences. These alterations, namely epigenetic changes, occur during cell division, differentiation and cell death. Numerous evidences demonstrate that epigenetic changes are governed by various types of determinants, including DNA methylation patterns, histone posttranslational modification signatures, histone variants, chromatin remodeling, and recently discovered chromosome conformation characteristics and noncoding RNAs (ncRNAs). Here, we highlight recent efforts on how the two latter epigenetic factors participate in the sophisticated transcriptional process and describe emerging techniques which permit us to uncover and gain insights into the fascinating genomic regulation.

Keywords

transcriptional regulation / long non-coding RNAs / three-dimensional chromosome interactions / epigenetic changes

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Jun Cao, Zhengyu Luo, Qingyu Cheng, Qianlan Xu, Yan Zhang, Fei Wang, Yan Wu, Xiaoyuan Song. Three-dimensional regulation of transcription. Protein Cell, 2015, 6(4): 241‒253 https://doi.org/10.1007/s13238-015-0135-7

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