Crystal structure of human Fanconi-associated nuclease 1

Peng-xian Yan, Yan-gao Huo, Tao Jiang

PDF(919 KB)
PDF(919 KB)
Protein Cell ›› 2015, Vol. 6 ›› Issue (3) : 225-228. DOI: 10.1007/s13238-014-0128-y
LETTER
LETTER

Crystal structure of human Fanconi-associated nuclease 1

Author information +
History +

Cite this article

Download citation ▾
Peng-xian Yan, Yan-gao Huo, Tao Jiang. Crystal structure of human Fanconi-associated nuclease 1. Protein Cell, 2015, 6(3): 225‒228 https://doi.org/10.1007/s13238-014-0128-y

References

[1]
Chaudhury I, Stroik DR, Sobeck A (2014) FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks. Mol Cell Biol34: 3939-3954
CrossRef Google scholar
[2]
Douwel DK, Boonen RACM, Long DT, Szypowska AA, Raschle M, Walter JC, Knipscheer P (2014) XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol Cell54: 460-471
CrossRef Google scholar
[3]
Fu YV, Yardimci H, Long DT, Ho TV, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Scharer OD, Walter JC (2011) Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell146: 930-940
CrossRef Google scholar
[4]
Gwon GH, Kim Y, Liu Y, Watson AT, Jo A, Etheridge TJ, Yuan FH, Zhang Y, Kim YC, Carr AM (2014) Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5’ flap DNA: basis of interstrand cross-link repair by FAN1. Genes Dev28: 2276-2290
CrossRef Google scholar
[5]
Huang J, Liu S, Bellani MA, Thazhathveetil AK, Ling C, de Winter JP, Wang YS, Wang WD, Seidman MM (2013) The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks. Mol Cell52: 434-446
CrossRef Google scholar
[6]
Kratz K, Schopf B, Kaden S, Sendoel A, Eberhard R, Lademann C, Cannavo E, Sartori AA, Hengartner MO, Jiricny J (2010) Deflciency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell142: 77-88
CrossRef Google scholar
[7]
Lans H, Hoeijmakers JH (2012) Genome stability, progressive kidney failure and aging. Nat Genet44: 836-838
CrossRef Google scholar
[8]
Liu T, Ghosal G, Yuan J, Chen J, Huang J (2010) FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science329: 693-696
CrossRef Google scholar
[9]
MacKay C, Declais AC, Lundin C, Agostinho A, Deans AJ, MacArtney TJ, Hofmann K, Gartner A, West SC, Helleday T (2010) Identiflcation of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell142: 65-76
CrossRef Google scholar
[10]
Moldovan GL, D’Andrea AD (2009) How the Fanconi anemia pathway guards the genome. Annu Rev Genet43: 223-249
CrossRef Google scholar
[11]
O’Donnell L, Durocher D (2010) DNA repair has a new FAN1 club. Mol Cell39: 167-169
CrossRef Google scholar
[12]
Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiacovo MP (2010) A genetic screen identifles FAN1, a Fanconi anemiaassociated nuclease necessary for DNA interstrand crosslink repair. Mol Cell39: 36-47
CrossRef Google scholar
[13]
Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP (2014) DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science346: 1127-1130
CrossRef Google scholar
[14]
Zhang J, Walter JC (2014) Mechanism and regulation of incisions during DNA interstrand cross-link repair. DNA Repair19: 135-142
CrossRef Google scholar
[15]
Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY (2012) FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet44: 910-915
CrossRef Google scholar

RIGHTS & PERMISSIONS

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
AI Summary AI Mindmap
PDF(919 KB)

Accesses

Citations

Detail

Sections
Recommended

/