Why is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis

Xuejun C. Zhang, Jianfeng Liu, Daohua Jiang

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Protein Cell ›› 2014, Vol. 5 ›› Issue (7) : 492-495. DOI: 10.1007/s13238-014-0062-z
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Why is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis

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Xuejun C. Zhang, Jianfeng Liu, Daohua Jiang. Why is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis. Protein Cell, 2014, 5(7): 492‒495 https://doi.org/10.1007/s13238-014-0062-z

References

[1]
Cherezov V (2007) High-resolution crystal structure of an engineered human β2-adrenergic G protein coupled receptor. Science318(5854): 1258-1265
CrossRef Google scholar
[2]
Fenalti G (2014) Molecular control of delta-opioid receptor signalling. Nature506(7487): 191-196
CrossRef Google scholar
[3]
Galvez T (2001) Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J20(9): 2152-2159
CrossRef Google scholar
[4]
Goudet C (2005) Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. J Biol Chem280(26): 24380-24385
CrossRef Google scholar
[5]
Havlickova M (2002) The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gammaaminobutyrate B receptor. Mol Pharmacol62(2): 343-350
CrossRef Google scholar
[6]
Hlavackova V (2005) Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. EMBO J24(3): 499-509
CrossRef Google scholar
[7]
Hollenstein K (2013) Structure of class B GPCR corticotropinreleasing factor receptor 1. Nature499(7459): 438-443
CrossRef Google scholar
[8]
Huang S (2011) Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci USA108(37): 15480-15485
CrossRef Google scholar
[9]
Kniazeff J (2011) Dimers and beyond: the functional puzzles of class C GPCRs. Pharmacol Ther130(1): 9-25
CrossRef Google scholar
[10]
Kunishima N (2000) Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature407(6807): 971-977
CrossRef Google scholar
[11]
Lagerstrom MC, Schioth HB (2008) Structural diversity of G proteincoupled receptors and significance for drug discovery. Nat Rev Drug Discov7(4): 339-357
CrossRef Google scholar
[12]
Margeta-Mitrovic M, Jan YN, Jan LY (2001) Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci USA98(25): 14643-14648
CrossRef Google scholar
[13]
Okada T (2000) X-ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol130(1): 73-80
CrossRef Google scholar
[14]
Rasmussen SG (2011) Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature477(7366): 549-555
CrossRef Google scholar
[15]
Ray K (2007) Elucidation of the role of peptide linker in calciumsensing receptor activation process. J BiolChem282(8): 5310-5317
CrossRef Google scholar
[16]
Rondard P (2006) Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J Biol Chem281(34): 24653-24661
CrossRef Google scholar
[17]
Rondard P (2008) Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J27(9): 1321-1332
CrossRef Google scholar
[18]
Trejo J, Connolly AJ, Coughlin SR (1996) The cloned thrombin receptor is necessary and sufficient for activation of mitogenactivated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem271(35): 21536-21541
CrossRef Google scholar
[19]
Wang C (2013) Structure of the human smoothened receptor bound to an antitumour agent. Nature497(7449): 338-343
CrossRef Google scholar
[20]
Wu B (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science330(6007): 1066-1071
CrossRef Google scholar
[21]
Wu H (2014) Structure of a Class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science
CrossRef Google scholar
[22]
Zhang XC (2013) GPCR activation: protonation and membrane potential. Protein Cell4(10): 747-760
CrossRef Google scholar

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2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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