Regulation of TLR7/9 signaling in plasmacytoid dendritic cells

Abstract

Plasmacytoid dendritic cells (pDCs), also known as type I interferon (IFN)-producing cells, are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nucleic acids derived from virus, bacteria or dead cells. PDCs selectively express endosomal Toll-like receptor (TLR) 7 and TLR9, which sense viral RNA and DNA respectively. Following type I IFN and cytokine responses, pDCs differentiate into antigen presenting cells and acquire the ability to regulate T cell-mediated adaptive immunity. The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance, inflammation and tumor microenvironments. In this review, we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors.

Keywords

plasmacytoid dendritic cells / Toll-like receptors / immunoreceptor tyrosine-based activation motif / immunoreceptor tyrosine-based inhibitory motif / immunoglobulin-like transcript / BDCA2 / phospholipid scramblase 1 / protein kinase C and casein kinase substrate in neurons 1