Direct lineage conversion: induced neuronal cells and induced neural stem cells

Abstract

Cellular reprogramming to neural cells is an area of ongoing study in developmental neuroscience, and recent research has generated remarkable achievements. Several studies have shown that the ectopic expression of specific neural transcription factors can convert terminally differentiated cells into neural cells. Here, we review the most recent progress in the field of induced neuronal (iN) cells and induced neural stem (iNS) cells and their potential clinical applications.

Keywords

iN cells / iNS cells / conversion / reprogramming / neuron / fibroblast