“Smurf”-ing tumors on the chromatin through RNF20

References

[1] Chandrasekharan, M.B., Huang, F., and Sun, Z.W. (2009). Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc Natl Acad Sci U S A 106, 16686-16691 .10.1073/pnas.0907862106
[2] Chandrasekharan, M.B., Huang, F., and Sun, Z.W. (2010). Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. Epigenetics 5, 460-468 .10.4161/epi.5.6.12314
[3] Fierz, B., Chatterjee, C., McGinty, R.K., Bar-Dagan, M., Raleigh, D.P., and Muir, T.W. (2011). Histone H2B ubiquitylation disrupts localand higher-order chromatin compaction. Nat Chem Biol 7, 113-119 .10.1038/nchembio.501
[4] Fukuchi, M., Fukai, Y., Masuda, N., Miyazaki, T., Nakajima, M., Sohda, M., Manda, R., Tsukada, K., Kato, H., and Kuwano, H. (2002). High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Res 62, 7162-7165 .
[5] Jason, L.J., Moore, S.C., Lewis, J.D., Lindsey, G., and Ausió, J. (2002). Histone ubiquitination: a tagging tail unfolds? Bioessays 24, 166-174 .10.1002/bies.10038
[6] Jin, C., Yang, Y.A., Anver, M.R., Morris, N.,Wang, X., and Zhang, Y.E. (2009). Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.Cancer Res 69, 735-740 .10.1158/0008-5472.CAN-08-1463
[7] Kouzarides, T. (2007). Chromatin modifications and their function. Cell 128, 693-705 .10.1016/j.cell.2007.02.005
[8] Misteli, T. (2007). Beyond the sequence: cellular organization of genome function. Cell 128, 787-800 .10.1016/j.cell.2007.01.028
[9] Narimatsu, M., Bose, R., Pye, M., Zhang, L., Miller, B., Ching, P., Sakuma, R., Luga, V., Roncari, L., Attisano, L., . (2009). Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell 137, 295-307 .10.1016/j.cell.2009.02.025
[10] Shema, E., Tirosh, I., Aylon, Y., Huang, J., Ye, C., Moskovits, N., Raver-Shapira, N., Minsky, N., Pirngruber, J., Tarcic, G., . (2008). The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev 22, 2664-2676 .10.1101/gad.1703008
[11] Yamashita, M., Ying, S.X., Zhang, G.M., Li, C., Cheng, S.Y., Deng, C. X., and Zhang, Y.E. (2005). Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121, 101-113 .
[12] Zhang, H., Teng, Y., Kong, Y., Kowalski, P.E., and Cohen, S.N. (2008). Suppression of human tumor cell proliferation by Smurf2-induced senescence. J Cell Physiol 215, 613-620 .10.1002/jcp.21337