Transcriptional activators and activation mechanisms

Abstract

Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.

Keywords

activator / transcription / co-activator / enhancer / promoter / signal transduction / development