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Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis
Xiao-Xi Guo1, Hanna Kim2, Yang Li1, Hyungshin Yim2, Seung Ki Lee2(), Ying-Hua Jin1(
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Protein Cell ›› 2011, Vol. 2 ›› Issue (7) : 543-553.
Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis
Sequential activation of cyclin-dependent kinases (Cdks) controls mammalian cell cycle. Here we demonstrate that the upregulation of cyclin-dependent kinase 2 (Cdk2) activity coincides with the loss of mitochondrial membrane potential (MMP) in paclitaxel-induced apoptosis. Ectopic expression of the dominant negative Cdk2 (Cdk2-dn) and a specific Cdk2 inhibitor, p21
apoptosis / cyclin-dependent kinase 2 / cytochrome c release / mitochondrial membrane potential / paclitaxel
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