Retinoic acid inducible gene-I, more than a virus sensor

Feng Liu, Jun Gu()

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Protein Cell ›› 2011, Vol. 2 ›› Issue (5) : 351-357. DOI: 10.1007/s13238-011-1045-y
MINI-REVIEW

Retinoic acid inducible gene-I, more than a virus sensor

  • Feng Liu, Jun Gu()
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Abstract

Retinoic acid inducible gene-I (RIG-I) is a caspase recruitment domain (CARD) containing protein that acts as an intracellular RNA receptor and senses virus infection. After binding to double stranded RNA (dsRNA) or 5′-triphosphate single stranded RNA (ssRNA), RIG-I transforms into an open conformation, translocates onto mitochondria, and interacts with the downstream adaptor mitochondrial antiviral signaling (MAVS) to induce the production of type I interferon and inflammatory factors via IRF3/7 and NF-κB pathways, respectively. Recently, accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events, such as inflammation and inflammation related diseases, cell proliferation, apoptosis and even senescence. Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields.

Keywords

retinoic acid inducible gene-I (RIG-I) / antiviral signaling / inflammation / innate immunity

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Feng Liu, Jun Gu. Retinoic acid inducible gene-I, more than a virus sensor. Prot Cell, 2011, 2(5): 351‒357 https://doi.org/10.1007/s13238-011-1045-y

References

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