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An unexpected similarity between antibiotic-resistant NDM-1 and beta-lactamase II from
Beiwen Zheng1,2, Shuguang Tan1,2, Jia Gao1,3, Huiming Han1,2, Jun Liu1, Guangwen Lu1,2, Di Liu1,4, Yong Yi5, Baoli Zhu1, George F. Gao1,2,6()
Protein Cell ›› 2011, Vol. 2 ›› Issue (3) : 250-258.
An unexpected similarity between antibiotic-resistant NDM-1 and beta-lactamase II from
NDM-1 (New Delhi metallo-beta-lactamase) gene encodes a metallo-beta-lactamase (MBL) with high carbapenemase activity, which makes the host bacterial strain easily dispatch the last-resort antibiotics known as carbapenems and cause global concern. Here we present the bioinformatics data showing an unexpected similarity between NDM-1 and beta-lactamase II from
NDM-1 /
metallo-β-lactamase /
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