The late stage of autophagy: cellular events and molecular regulation

Jingjing Tong1,2, Xianghua Yan2, Li Yu1()

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Protein Cell ›› 2010, Vol. 1 ›› Issue (10) : 907-915. DOI: 10.1007/s13238-010-0121-z
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The late stage of autophagy: cellular events and molecular regulation

  • Jingjing Tong1,2, Xianghua Yan2, Li Yu1()
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Abstract

Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation. It is a “self-eating” process and plays a “house-cleaner” role in cells. The complex process consists of several sequential steps—induction, autophagosome formation, fusion of lysosome and autophagosome, degradation, efflux transportation of degradation products, and autophagic lysosome reformation. In this review, the cellular and molecular regulations of late stage of autophagy, including cellular events after fusion step, are summarized.

Keywords

autophagy / autophagosome / lysosome / fusion / degradation

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Jingjing Tong, Xianghua Yan, Li Yu. The late stage of autophagy: cellular events and molecular regulation. Prot Cell, 2010, 1(10): 907‒915 https://doi.org/10.1007/s13238-010-0121-z

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