Chemotaxis: new role for Ras revealed

Jianshe Yan1(), Dale Hereld2, Tian Jin1

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Protein Cell ›› 2010, Vol. 1 ›› Issue (10) : 879-880. DOI: 10.1007/s13238-010-0119-6
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Chemotaxis: new role for Ras revealed

  • Jianshe Yan1(), Dale Hereld2, Tian Jin1
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Jianshe Yan, Dale Hereld, Tian Jin. Chemotaxis: new role for Ras revealed. Prot Cell, 2010, 1(10): 879‒880 https://doi.org/10.1007/s13238-010-0119-6

References

[1] Cai, H., Das, S., Kamimura, Y., Long, Y., Parent, C.A., and Devreotes, P.N. (2010). Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol 190, 233–245 .10.1083/jcb.201001129
[2] Charest, P.G., Shen, Z., Lakoduk, A., Sasaki, A.T., Briggs, S.P., and Firtel, R.A. (2010). A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell 18, 737–749 .10.1016/j.devcel.2010.03.017
[3] Chen, L., Iijima, M., Tang, M., Landree, M.A., Huang, Y.E., Xiong, Y., Iglesias, P.A., and Devreotes, P.N. (2007). PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 12, 603–614 .10.1016/j.devcel.2007.03.005
[4] Jin T, Xu X, Fang J, Isik N, Yan J, Brzostowski JA, Hereld D. (2009). How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol Res 43, 118–27 .10.1007/s12026-008-8056-7
[5] Kamimura, Y., Xiong, Y., Iglesias, P.A., Hoeller, O., Bolourani, P., and Devreotes, P.N. (2008). PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol 18, 1034–1043 .10.1016/j.cub.2008.06.068
[6] Kamimura, Y., and Devreotes, P.N. (2010). Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem 285, 7938–7946 .10.1074/jbc.M109.089235
[7] Lee, S., Comer, F.I., Sasaki, A., McLeod, I.X., Duong, Y., Okumura, K., Yates, J.R., Parent, C.A., and Firtel, R.A. (2005). TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell 16, 4572–4583 .10.1091/mbc.E05-04-0342
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