Analysis of Risk Factors for Adjacent Segment Disease After Lumbar Facet Joint Fusion

Haibiao Qin , Jinglong Yan , Guangxi Wang , Hui Chi , Xu Zhang , Pengyu Kong , Chunyang Xi

Orthopaedic Surgery ›› 2026, Vol. 18 ›› Issue (3) : 433 -442.

PDF (738KB)
Orthopaedic Surgery ›› 2026, Vol. 18 ›› Issue (3) :433 -442. DOI: 10.1111/os.70250
CLINICAL ARTICLE
Analysis of Risk Factors for Adjacent Segment Disease After Lumbar Facet Joint Fusion
Author information +
History +
PDF (738KB)

Abstract

Objective: Insufficient correction of segmental lordosis is an important risk factor for adjacent segment disease (ASD). This study aimed to investigate the relationship between segmental lordosis–related parameters and ASD following lumbar facet joint fusion (FJF).

Methods: A retrospective analysis was conducted on 29 patients who underwent revision surgery for ASD after posterior lumbar fusion at our institution between February 2014 and February 2024. A matched control group of 29 non-ASD patients was selected based on age at initial surgery, sex, fusion level, and follow-up duration. Preoperative, postoperative, and final follow-up lumbar radiographs were analyzed. Parameters assessed included lumbar lordosis (LL), segmental lordosis (SL), sacral slope (SS), and relative disc height of adjacent segments. General baseline characteristics, sagittal parameters before and after the initial surgery, and correction values of sagittal alignment were compared between the two groups. Parameters showing significant differences were further analyzed using binary logistic regression, and receiver operating characteristic (ROC) curves were used to determine predictive thresholds of independent risk factors for ASD.

Results: There were no significant differences in baseline characteristics between the two groups (p > 0.05). After the primary fusion surgery, LL and SS were significantly lower in the ASD group compared with the control group (p < 0.05). Regarding sagittal correction, the relative change in SL (r△SL) was significantly smaller in the ASD group (p < 0.05), confirming insufficient local curvature reconstruction. Logistic regression identified r△SL as an independent risk factor for ASD (p = 0.004, OR = 0.976, 95% CI: 0.960–0.992). ROC curve analysis revealed an area under the curve (AUC) of 0.712 (95% CI: 0.580–0.844), with an optimal predictive threshold of 2.6% for r△SL.

Conclusion: Insufficient correction of segmental lordosis is a key risk factor for ASD following lumbar facet joint fusion, and prioritizing the restoration of local sagittal alignment during surgery may effectively reduce the incidence of postoperative ASD.

Keywords

adjacent segment disease / posterior lumbar fusion / segmental lordosis / spine

Cite this article

Download citation ▾
Haibiao Qin, Jinglong Yan, Guangxi Wang, Hui Chi, Xu Zhang, Pengyu Kong, Chunyang Xi. Analysis of Risk Factors for Adjacent Segment Disease After Lumbar Facet Joint Fusion. Orthopaedic Surgery, 2026, 18 (3) : 433-442 DOI:10.1111/os.70250

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Z. J. Ma, X. Y. Liu, J. Q. Zhang, et al., “Comparative Analysis of the Efficacy of Three Lumbar Fixation and Fusion Procedures in the Treatment of Adjacent Segment Disease After Lumbar Surgery,” Chinese Journal of Spine and Spinal Cord 32, no. 12 (2022): 1102–1111.

[2]

W. R. Sears, I. G. Sergides, N. Kazemi, M. Smith, G. J. White, and B. Osburg, “Incidence and Prevalence of Surgery at Segments Adjacent to a Previous Posterior Lumbar Arthrodesis,” Spine Journal 11, no. 1 (2011): 11–20.

[3]

C. Xi, Y. Li, Z. Chi, et al., “The Influence of Orthotopic Paraspinal Muscle-Pediculated Bone Flaps on Posterior Spinal Fusion in a Canine Model,” Spine (Phila Pa 1976) 36, no. 1 (2011): E20–E26.

[4]

Z. Y. Gong, H. L. Wang, and X. S. Ma, “Risk Factors for Adjacent Segment Disease After Posterior L4/5 Fusion Surgery,” Chinese Journal of Spine and Spinal Cord 33, no. 4 (2023): 337–343.

[5]

S. Umehara, M. R. Zindrick, A. G. Patwardhan, et al., “The Biomechanical Effect of Postoperative Hypolordosis in Instrumented Lumbar Fusion on Instrumented and Adjacent Spinal Segments,” Spine (Phila Pa 1976) 25, no. 13 (2000): 1617–1624.

[6]

F. Y. Tsuang, J. C. Tsai, and D. M. Lai, “Effect of Lordosis on Adjacent Levels After Lumbar Interbody Fusion, Before and After Removal of the Spinal Fixator: A Finite Element Analysis,” BMC Musculoskeletal Disorders 20, no. 1 (2019): 470.

[7]

X. Zhao, L. Du, Y. Xie, and J. Zhao, “Effect of Lumbar Lordosis on the Adjacent Segment in Transforaminal Lumbar Interbody Fusion: A Finite Element Analysis,” World Neurosurgery 114 (2018): e114–e120.

[8]

J. S. Bae, S. H. Lee, J. S. Kim, B. Jung, and G. Choi, “Adjacent Segment Degeneration After Lumbar Interbody Fusion With Percutaneous Pedicle Screw Fixation for Adult Low-Grade Isthmic Spondylolisthesis: Minimum 3 Years of Follow-Up,” Neurosurgery 67, no. 6 (2010): 1600–1607.

[9]

H. Nakashima, N. Kawakami, T. Tsuji, et al., “Adjacent Segment Disease After Posterior Lumbar Interbody Fusion: Based on Cases With a Minimum of 10 Years of Follow-Up,” Spine (Phila Pa 1976) 40, no. 14 (2015): E831–E841.

[10]

Y. Takahashi, S. Okuda, Y. Nagamoto, T. Matsumoto, T. Sugiura, and M. Iwasaki, “Effect of Segmental Lordosis on the Clinical Outcomes of 2-Level Posterior Lumbar Interbody Fusion for 2-Level Degenerative Lumbar Spondylolisthesis,” Journal of Neurosurgery. Spine 31, no. 5 (2019): 670–675.

[11]

S. R. Bagheri, E. Alimohammadi, A. Zamani Froushani, and A. Abdi, “Adjacent Segment Disease After Posterior Lumbar Instrumentation Surgery for Degenerative Disease: Incidence and Risk Factors,” Journal of Orthopaedic Surgery (Hong Kong) 27, no. 2 (2019): 2309499019842378.

[12]

S. J. Wang, S. B. Zhang, Y. Y. Yi, H. W. Xu, and D. S. Wu, “Estimation of the Ideal Correction of Lumbar Lordosis to Prevent Reoperation for Symptomatic Adjacent Segment Disease After Lumbar Fusion in Older People,” BMC Musculoskeletal Disorders 21, no. 1 (2020): 429.

[13]

L. A. Toivonen, H. Mäntymäki, A. Häkkinen, H. Kautiainen, and M. H. Neva, “Postoperative Sagittal Balance Has Only a Limited Role in the Development of Adjacent Segment Disease After Lumbar Spine Fusion for Degenerative Lumbar Spine Disorders: A Subanalysis of the 10-Year Follow-Up Study,” Spine (Phila Pa 1976) 47, no. 19 (2022): 1357–1361.

[14]

Z. Gong, D. Li, F. Zou, S. Liu, H. Wang, and X. Ma, “Low Lumbar Multifidus Muscle Status and Bone Mineral Density Are Important Risk Factors for Adjacent Segment Disease After Lumbar Fusion: A Case–Control Study,” Journal of Orthopaedic Surgery and Research 17, no. 1 (2022): 490.

[15]

Q. Wang, Z. Gao, K. Guo, F. Wang, and D. Wu, “Effect of Sagittal Screw Angle and Distance of Screw Apex to Superior Endplate on Adjacent Segment Disease After Posterolateral Lumbar Fusion: A Retrospective Study,” Journal of Orthopaedic Surgery and Research 17, no. 1 (2022): 486.

[16]

T. Wang and W. Ding, “Risk Factors for Adjacent Segment Degeneration After Posterior Lumbar Fusion Surgery in Treatment for Degenerative Lumbar Disorders: A Meta-Analysis,” Journal of Orthopaedic Surgery and Research 15, no. 1 (2020): 582.

RIGHTS & PERMISSIONS

2026 The Author(s). Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.

PDF (738KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/