Organoids: Current status and prospects (2025)

Abstract

Organoids have attracted increasing attention from academia, industry, and regulatory agencies. At the turn of 2025-2026, we review recent breakthroughs in organoid technology and outline the major challenges currently faced in the field. We encourage broader participation to advance organoid technologies, overcome key bottlenecks, and further enable applications in disease research and innovative drug development.

Keywords

Organoid / Progress / Bottlenecks / Drug development

Acknowledgments

None.

Funding

None.

Conflict of interest

Rui L. Reis is the Honorary Editor-in-Chief of this journal, but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, other authors declared that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.

Author contributions

Conceptualization: Leping Yan

Visualization: Wei Chen

Writing-original draft: Wei Chen

Writing-review & editing: Leping Yan, Joaquim M. Oliveria, Rui L. Reis, Changhua Zhang, Yulong He

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data

Not applicable.

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