A trabeculae-like biomimetic bone-filling material as a potential organoid for bone defect treatment

Abstract

Bone-filling materials are critical tools for the treatment of bone defects. However, existing materials require improvements in tissue compatibility and drug-loading capacity. In this study, we designed and synthesized a novel trabeculae-like biomimetic bone-filling material (TBM) that mimics the composition and structure of natural bone trabecular tissue. This TBM demonstrated high mechanical strength and excellent biocompatibility. It effectively embedded osteogenic cells and potentially functioned as an organoid. We demonstrated that the TBM exhibited therapeutic efficacy in treating various bone defects and fractures by filling defect regions and enabling sustained release of small-molecule and nucleic acid drugs. Based on these findings, we propose TBM as a promising candidate for the treatment of bone defects and provide innovative insights for the development of bone-filling materials.

Keywords

Bone-filling material / Organoid / Bone defect / Tissue engineering

References

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