A fast streptomycin sulfate sensing based on Nb₂CT_X functionalized titled fiber Bragg grating

Abstract

We proposed a fast and temperature self-compensation method to detect streptomycin sulfate aqueous solution concentration based on two-dimensional (2D) Nb₂CT_X MXene nanosheets functionalized tilted fiber Bragg grating (N-TFBG). The introduction of 2D Nb₂CT_X MXene nanosheets brought more than 100% increase in sensitivity and exhibited a high sensitivity of 253.8 pm·mg⁻¹·mL⁻¹ and a detection limit of 80 µg/mL in range of 0.2–0.8 mg/mL. Due to high sensitivity and compact structure, the N-TFBG sensor has a faster measure speed than previous method. Additionally, the sensor has simultaneous temperature measurement by detecting the cladding mode and the core mode resonance peak simultaneously. Our research will supply a new research platform for online detection of streptomycin sulfate concentration.

Keywords

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References

[1] Dong L, Mu L, Huang X. Exploring lipid remodeling and antioxidant responses in chlorella pyrenoidosa exposed to streptomycin sulfate stress. Food chemistry. 2025, 478(30): 143565 J]

[2] Holzgrab U, Nap C, Kunz N, et al. . Identification and control of impurities in streptomycin sulfate by high-performance liquid chromatography coupled with mass detection and corona charged-aerosol detection. Journal of pharmaceutical and biomedical analysis. 2011, 56: 271 J]

[3] Marina S R, Juan M F R, Agustina G H. Determination of aminoglycoside antibiotics using an on-chip microfluidic device with chemiluminescence detection. Microchimica acta. 2012, 179: 185-192 J]

[4] Byzova N A, Zvereva E A, Zherdev A V, et al. . Pretreatment-free immunochromatographic assay for the detection of streptomycin and its application to the control of milk and dairy products. Analytica chimica acta. 2011, 701: 209 J]

[5] Xiong B L, Qiu X M, Chen S, et al. . A study on the detection methods of streptomycin sulfate. Yunnan chemical technology. 2019, 46(5): 82[J]

[6] Wang L, Wang H, Huang S, et al. . Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. Food chemistry. 2023, 403: 134399 J]

[7] Liu X, He M, Tang S. Effect of environmental temperature on determining abnormal toxicity of streptomycin sulfate in mice. Laboratory animal science. 1992, 9(3): 18-20[J]

[8] Patil K C, Dudhe C. Studies on thermodynamic properties of streptomycin aqueous solution from T=(298.15 to 308.15)K. Der pharma chemica. 2015, 7(9): 239-249[J]

[9] Shao M, Wang M, Yuan Y, et al. . Wearable optical fiber sensor in no-core fiber for heart rate monitoring. Optics and laser technology. 2025, 192: 113404 J]

[10] Wang F, Zhou X, Zhang J, et al. . Optical fiber TFBG glucose biosensor via pH-sensitive polyelectrolyte membrane. Biosensor. 2025, 15(10): 642 J]

[11] Jiang B Q, Zhou K M, Wang C L, et al. . Label-free glucous biosensor based on enzymatic graphene oxide-functionalized tilted fiber grating. Sensor and actuators B: chemical. 2018, 254: 1033-1039 J]

[12] Liu H, Liu M, Guo S. Advanced optic-fiber sensor for progesterone concentration detection relying on the temperature-compensated reflective structure reflective structure functionalized with molecularly imprinted polymer. Food chemistry: X. 2025, 29: 102742[J]

[13] Qu H, Ma S, Marques C, et al. . TFBGs in polymide-coated optical fibers for multi-parameter measurements. Optics express. 2025, 33(14): 29322-29336 J]

[14] Fang S, Feng X, Cao Y, et al. . Surface plasmon resonance based ultra-sensitive cholesterol detection using AuNPs/MPBA/ β-CD fimctionalized gold-coated tilted fiber Bragg grating. Sensors and actuators B: chemical. 2025, 443(15): 138227 J]

[15] Yang W, Cheng Y Y, Jiang M S, et al. . Design and fabrication of an ultra-sensitive Ta₂C Mxene/Au-coated tilted grating sensor. Sensors and actuators B: chemical. 2022, 369: 132391 J]

[16] Chen Y Z, Ge Y Q, Huang W C, et al. . Refractive index sensors based on Ti₃C₂T_x MXene fiber. ACS applied nano materials. 2020, 3(1): 303-311 J]

[17] Li G R, Singh R, Guo J J, et al. . Nb₂CT_x MXene-assisted double S-tapered fiber-based LSPR sensor with improved features for tyramine detection. Applied physics letters. 2023, 112: 083701 J]

[18] Zhou K M, Zhang L, Chen X F, et al. . Low thermal sensitivity grating devices based on ex-45° tilting structure capable of forward-propagating cladding modes coupling. Journal of lightwave technology. 2006, 24(12): 5087-5094 J]

[19] Bi M P, Miao Y P, Li W J, et al. . Ultrasensitive BOD detection of fiber integrated with Nb₂CT_X MXene for water pollution. Journal of lightwave technology. 2022, 40(7): 2173 J]

[20] Bi M P, Miao Y P, Li W J, et al. . Niobium carbide MXene-optics fiber sensor for high sensitivity humidity detection. Applied physics letters. 2022, 120: 021103 J]

[21] Zhang Z B, Jia X R, Xu X Q. An electrochemical aptasensor for detection of streptomycin based on signal amplification assisted by functionalized gold nanoparticles and hybridization chain reaction. Microchimica acta. 2023, 152: 190[J]

[22] Chan C L, Wai H K F, Wu P, et al. . A universal LC-MS/MS method for simultaneous detection of antibiotic residues in animal and environmental samples. Antibiotics. 2011, 11: 845 J]

[23] Naqvi S S, Anwar H, Noori M Y, et al. . Silver nanoparticles as a nanoprobe for trace level simultaneous detection of streptomycin sulfate and isoniazid and anti-TB activity of their nanoparticles complexes. Journal of molecular structure. 2023, 1275: 134634 J]

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Tianjin University of Technology