Optimizing light delivery in scanning photoacoustic imaging for prostate

Abstract

The purpose of this study was to optimize the light delivery method in a prostate photoacoustic imaging system. A three dimensional (3D) optical model of the human prostate was developed, and the optical energy distribution in the prostate was estimated via three-dimensional Monte Carlo simulation. Then, the feasibility of prostate photoacoustic imaging (PAI) using two endoscopic light delivery methods was studied. Photoacoustic pressure generation and the corresponding photoacoustic images had been obtained and the comparisons were made between each other. Also, the results of cylinder diffusing light source with different lengths were compared. After that, phantom experiment was carried out to validate the simulation results. Our results would be significant in the optimizing photoacoustic imaging system for an accurate diagnosis of prostate cancer.

References

[1] SiegelR L, MillerK D, JemalA. Cancer Statistics, CA: A Cancer Journal for Clinicians, 2018, 68: 7

[2] WangX, RobertsW W, CarsonP L, WoodD P, FowlkesJ B. Biomedical Optics Express, 2010, 1: 1117

[3] KothapalliS R, SonnG A, ChoeJ W, NikoozadehA, BhuyanA, ParkK K, CristmanP, FanR, MoiniA, LeeB C, WuJ, CarverT E, TrivediD, ShiibaL, SteinbergI, HulandD M, RasmussenM F, LiaoJ C, BrooksJ D, Khuri-YakubP T, GambhirS S. Science Translational Medicine, 2019, 11: eaav2169

[4] DograV S, ChinniB K, ValluruK S, JosephJ V, GhaziA, YaoJ L, EvansK, MessingE M, RaoN A. Journal of Clinical Imaging Scienc, 2013, 3: 41

[5] AgarwalA, HuangS W, DonnellM O, DayK C, DayM, KotovN, AshkenaziS. Journal of Applied Physics, 2007, 102: 064701

[6] YaseenM A, ErmilovS A, BrechtH, SuR, ConjusteauA, FronheiserM, BellB A, MotamediM, OraevskyA A. Journal of Biomedical Optics, 2010, 15: 21310

[7] K Valluru, B Chinni, S Bhatt, V Dogra, N A Rao and D Akata, Probe Design for Photoacoustic Imaging of Prostate, IEEE International Conference on Imaging Systems and Techniques, 121 (2010).

[8] HoriguchiA, ShinchiM, NakamuraA, WadaT, ItoK, AsanoT, ShinmotoH, TsudaH, IshiharaM. Urology, 2017, 108: 212

[9] LiuC B, XingM Y, CongB, QiuC, HeD, WangC Z, XiaoY, YinT H, ShaoM, QiuW B, MaT, GongX J, ChenX, ZhengH R, ZhengR Q, SongL. Biomedical Optics Express, 2019, 10: 1707

[10] W M Xie, L Li, Z F Li and H Li, Photoacoustic Imaging of Prostate Cancer using Cylinder Diffuse Radiation, Proceedings of SPIE, 85532V (2012).

[11] BellM A L, KuoN P, SongD Y, KangJ U, BoctorE M. Journal of Biomedical Optics, 2014, 19: 126011

[12] BellM A L, GuoX Y, SongD Y, BoctorE M. Journal of Biomedical Optics, 2015, 20: 036002

[13] AiM, YounJ I, SalcudeanS E, RohlingR, AbolmaesumiP, TangS. Biomedical Optical Express, 2019, 10: 2588

[14] BungartB, CaoY C, Yang-TranT, GorskyS, LanL, RoblyerD, KochM O, ChengL, MastersonT, ChengJ X. Biomedical Optics Express, 2019, 10: 1405

[15] JacquesS L. Photoacoustics, 2014, 2: 137

[16] Vo-DinhT. Biomedical Photonics Handbook, 2003, BocaRaton, CRC Press

[17] BoasD, PitrisC, RamanujamN. Handbook of Biomedical Optics, 2011, Boca Raton, CRC Press

[18] P Agrba, M Kirillin, A Abelevich and V Kamensky, Mechanical Compression for Biotissue Image Enhancement in Optical Coherence Tomography, Proceedings of SPIE, 754703 (2010).

[19] SvenssonT, Andersson-EngelsS, EinarsdóttírM, SvanbergK. Journal of Biomedical Optics, 2007, 2: 014022

[20] El-GoharyS H, MetwallyM K, EomS, JeonS H, ByunK M, KimT S. Biomedical Engineering Letters, 2014, 4: 250

[21] TangS, ChenJ, SamantP, StrattonK, XiangL. IEEE Transactions on Medical Imaging, 2016, 35: 1780

[22] PengD Q, PengY Y, GuoJ, LiH. Laser Illumination Modality of Photoacoustic Imaging Technique for Prostate Cancer. Journal of Physics: Conference Series, 2016, 679: 012026