Noninvasive photoacoustic measurement of absorption coefficient using internal light irradiation of cylindrical diffusing fiber

Abstract

Absorption coefficient of biological tissue is an important parameter in biomedicine, but its determination remains a challenge. In this paper, we propose a method using focusing photoacoustic imaging technique and internal light irradiation of cylindrical diffusing fiber (CDF) to quantify the target optical absorption coefficient. Absorption coefficients for ink absorbers are firstly determined through photoacoustic and spectrophotometric measurements at the same excitation, which demonstrates the feasibility of this method. Also, the optical absorption coefficients of ink absorbers with several concentrations are measured. Finally, the two-dimensional scanning photoacoustic image is obtained. Optical absorption coefficient measurement and simultaneous photoacoustic imaging of absorber non-invasively are the typical characteristics of the method. This method can play a significant role for non-invasive determination of blood oxygen saturation, the absorption-based imaging and therapy.

References

[1] XuM, WangLV. Review of Scientific Instruments, 2006, 77: 041101

[2] ZhangT, WangC, WengX-f, WeiX-b. Journal of Optoelectronics·Laser, 2015, 26: 2241

[3] SalehiHS, KumavorPD, LiH, AlqasemiU, WangTH, XuC, ZhuQ. Photoacoustics, 2015, 3: 114

[4] Kuniyil Ajith SinghM, ParameshwarappaV, HendriksenE, SteenbergenW, ManoharS. Journal of Biomedical Optics, 2016, 21: 120501

[5] HirasawaT, FujitaM, OkawaS, KushibikiT, IshiharaM. Applied Optics, 2013, 52: 8562

[6] LinL, YaoJ, LiL, WangLV. Journal of Biomedical Optics, 2016, 21: 061002

[7] WangY, WangR. Physics in Medicine Biology, 2008, 53: 6167

[8] YuanZ, WangQ, JiangH. Optics Express, 2007, 15: 18076

[9] YuanZ, JiangH. Phiols. Transact. A Math. Phys. Eng. Sci., 2009, 367: 3043

[10] LiX, JiangH. Physics in Medicine & Biology, 2013, 58: 999

[11] HirasawaT, FujitaM, OkawaS, KushibikiT, IshiharaM. Proceedings of SPIE 8581, 2013,

[12] HirasawaT, OkawaS, FujitaM, KushibikiT, IshiharaMQuantification of Optical Attenuation Coefficient Based on Continuous Wavelet Transform of Photoacoustic Signals Measured by a Focused Broadband Acoustic SensorConference on Photons Plus Ultrasound: Imaging and Sensing, 2014,

[13] PriyaM, Satish RaoBS, RayS, MahatoKK. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 127: 85

[14] CoxBT, ArridgeSR, KostliKP, BeardPC. Proceedings of SPIE, 2005, 49: 5697

[15] CoxBT, ArridgeSR, KostliKP, BeardPC. Applied Optics, 2006, 45: 1866

[16] XieW-m, LiH, LiZ-f, LiuH-q. Laser & Optoelectronics Progress, 2009, 46: 103

[17] LiZ, LiH, ZengZ, XieW, ChenW. Journal of Biomedical Optics, 2012, 17: 061216

[18] LiC, WangL V. Physics Medicine & Biology, 2009, 54: R59

[19] IrisawaK, HirasawaT, HirotaK, TsujitaK, IshiharaM. Proceedings of SPIE 8223, 2012,

[20] GuoZ, LiL, WangLV. Medical Physics, 2009, 36: 4084

[21] PengD-q, XieW-m, WuS-l, TangJ-m, LiZ-f, LiH. Acta. Phys. Sin., 2015, 64: 207801

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