Biological reaction signal enhancement in porous silicon Bragg mirror based on quantum dots fluorescence

Abstract

In this paper, we mainly study the preparation of an optical biosensor based on porous silicon (PSi) Bragg mirror and its feasibility for biological detection. The quantum dot (QD) labeled biotin was pipetted onto streptavidin functionalized PSi Bragg mirror samples, the affinity reaction between QD labeled biotin and streptavidin in PSi occurred, so the QDs were indirectly connected to the PSi. The fluorescence of QD enhanced the signal of biological reactions in PSi. The performance of the sensor is verified by detecting the fluorescence of the QD in PSi. Due to the fluorescence intensity of the QDs can be enhanced by PSi Bragg mirror, the sensitivity of the PSi optical biosensor will be improved.

References

[1] LinV. S., MoteshareiK., DancilK. P., SailorM. J., GhadiriM. R.. Science, 1997, 278: 840

[2] Xiao-yiL., Guo-dongL., Jia-qingM.O., LiangX.U., Zhen-hongJ.I.A.. Optoelectronics Letters, 2016, 12: 478

[3] SteinN. E., HamelersH. V. M., BuismanC. N. J.. Sensors & Actuators B Chemical, 2012, s171–172: 816

[4] NiuS., ZhaoM., HuL., ZhangS.. Sensors & Actuators B Chemical, 2008, 135: 200

[5] YakovlevaM., BhandS., DanielssonB.. Analytica Chimica Acta, 2013, 766: 1

[6] GaurG., KoktyshD. S., WeissS. M.. Advanced Functional Materials, 2013, 23: 3604

[7] JenieS. N., Prieto-SimonB., VoelckerN. H.. Biosensors & Bioelectronics, 2015, 74: 637

[8] LedentsovN. N., UstinovV. M., ShchukinV. A., Kop’EvP. S., AlferovZ. I., BimbergD.. Semiconductors, 1998, 32: 343

[9] MidgettA. G., HillhouseH. W., HughesB. K., NozikA. J., BeardM. C.. Journal of Physical Chemistry C, 2010, 114: 17486

[10] LordS. J., LeeH. D., MoernerW. E.. Analytical Chemistry, 2010, 82: 2192

[11] DorfnerD. F., HürlimannT., AbstreiterG., FinleyJ. J.. Applied Physics Letters, 2007, 91: 4648

[12] MoJ. Q., JiangJ., ZhaiZ. G., ShiF. G., JiaZ. H.. Optoelectronics Letters, 2017, 13: 10

[13] GaurG., KoktyshD., WeissS. M.. Mrs Online Proceeding Library, 2011, 1301: 463

[14] LiuC., JiaZ., LvX., LvC., ShiF.. Physica B Condensed Matter, 2014, 457: 263

[15] ZimbronM. J.. Zimbron Malcolm Jeremy, 2012,

[16] ReyesF. D., RomeroJ. M. F., CastroM. D. L. D.. Analytica Chimica A cta, 2001, 436: 109

Just Accepted

This article has successfully passed peer review and final editorial review, and will soon enter typesetting, proofreading and other publishing processes. The currently displayed version is the accepted final manuscript. The officially published version will be updated with format, DOI and citation information upon launch. We recommend that you pay attention to subsequent journal notifications and preferentially cite the officially published version. Thank you for your support and cooperation.