Label-free quantitative detection using porous silicon as optical biosensor

Fu-ru Zhong; Xiao-lin Ma; Xiao-yi Lü; Zhen-hong Jia

doi:10.1007/s11801-012-2244-3

Optoelectronics Letters ›› 2012, Vol. 8 ›› Issue (4) : 314-317. DOI: 10.1007/s11801-012-2244-3

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Label-free quantitative detection using porous silicon as optical biosensor

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Abstract

The single-layer porous silicon is prepared by electrochemistry etching method, which is used as an immunosensor for determining recombinant mouse zona pellucida 3 fusion protein (r-mZP3) by Raman spectroscopy analysis at room temperature. The molecule binding increases the effective optical thickness (EOT), and thus the Raman spectrum intensity decreases. The concentration and variation of Raman intensity show a good linear quantitative relation. The excellent sensing performance could open the way to a new family of optical sensors for biological standardization.

Keywords

Raman Spectrum / Porous Silicon / Raman Intensity / Porous Silicon Layer / Porous Silicon Sample

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Fu-ru Zhong, Xiao-lin Ma, Xiao-yi Lü, Zhen-hong Jia. Label-free quantitative detection using porous silicon as optical biosensor. Optoelectronics Letters, 2012, 8(4): 314‒317 https://doi.org/10.1007/s11801-012-2244-3

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This work has been supported by the National Natural Science Foundation of China (No.60968002), and the China Postdoctoral Science Foundation (No.2011M501501).