Chahine algorithm to invert light scattering spectroscopy of epithelial dysplasia

Abstract

To perceive the epithelial dysplasia from the light scattering spectroscopy (LSS) is an inverse problem, which can be transformed into the inversion of the size distribution of epithelial-cell nuclei. Based on the simulation of single polarized LSS for epithelial-cell nuclei, Chahine algorithm is adopted to retrieve the size distribution. Numerical results show that Chahine algorithm has high inversion precision for both single-peaked and bimodal models, which implies the potential to increase diagnostic resolution of LSS.

References

[1] BackmanV., WallaceM. B., PerelmanL. T.. Nature., 2000, 406: 35

[2] PerelmanL. T., BackmanV., WallaceM. B.. Phys. Rev. Lett., 1998, 80: 627

[3] BackmanV., GurjarR., BadizadeganK.. IEEE J. Select. Topics Quantum Electron., 1999, 5: 1019

[4] Bohren C F, Absorption and Scattering of Light by Small Particles, New York: John Wiley & Sons, 112.

[5] BeauvoitB., KitaiT., ChanceB.. Biophys.J, 1994, 67: 2501

[6] Wang Q H, Particle size and shape analysis with light scattering, Nanjing University of Technology, (2003), 42. ( in Chinese)

[7] ChahineM. T.. J. Atmos. Sci., 1970, 27: 960

[8] ChahineM. T.. J. Opt. Soc. Am., 1968, 58: 1634

[9] BassiniA.. Opt. Eng., 1992, 31: 1112