Immature platelet fraction as a clinical predictor for enhanced platelet recovery in patients with dengue fever

Abstract

Objective: To evaluate the potential of immature platelet fraction (IPF) as a predictor of increased platelets in dengue fever patients.
Methods: A cross-sectional study was conducted. We analyzed the medical records of confirmed dengue patients who were admitted to Udayana University Academic Hospital. Pearson correlation was used to assess the correlation between increased IPF and ratio of increased platelets in patients with dengue fever.
Results: Between June 2022 and December 2022, 41 patients were included in the study. Their mean age was 45.0 ± 18.5 years, with males comprising 60.0% of the cohort. The initial mean platelet count was 107.7 × 10³ cells/µL at baseline and increased to 128.1 × 10³ cells/µL by the end of the observation period. The mean IPF was 1.9 ± 1.6%. A moderate positive correlation was identified between IPF levels and the subsequent increase in platelet count two days after measurement.
Conclusions: IPF reflects the rate of thrombopoiesis in patients with thrombocytopenia and serves as an indicator of recovery in dengue fever patients.

Keywords

Immature platelet fraction / Dengue fever / Platelet count / Clinical predictor

Conflict of interest statement

The authors claim there is no conflict of interest.

Funding

This study receives no extramural funding.

Data availability statement

The data supporting the findings of this study are available from the corresponding author upon request.

Authors’ contributions

Somia IKA and Purnamasidhi CAW designed the study, data collection, manuscript writing, and manuscript review. Shanti DAFP, Purnama GV, and Adiputra IKH contributed to analyze the study, manuscript wring and manuscript editing. All authors approved the final version of the manuscript and agree to be accountable for the accuracy and integrity of the work.

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