Aim: Sleep traits are increasingly recognized as influential in the pathogenesis of various diseases, including perianal disorders. However, the causal mechanisms linking sleep to perianal conditions remain unclear. This study explores these relationships, evaluating sleep traits as risk factors and the feasibility of targeted sleep-related interventions.
Methods: We performed a genetic analysis utilizing genome-wide association study (GWAS) data from European populations to investigate the potential causal links between sleep traits and perianal diseases. A reverse genetic approach was also used to explore how perianal diseases might impact sleep traits. Sensitivity analyses were conducted to assess the robustness of the results.
Results: Our analysis identified sleep traits and disorders associated with an increased risk of hemorrhoidal disease, including insomnia (Odds Ratio [OR]: 1.232, 95% Confidence Interval [CI]: 1.103–1.376; p = 0.0002), sleep duration (OR: 1.162, 95% CI: 1.036–1.303; p = 0.010), daytime napping (OR: 1.141, 95% CI: 1.029–1.266; p = 0.012). In contrast, no inverse causal relationship between perianal disease and sleep disorders.
Conclusions: This study highlights a bidirectional relationship between sleep traits and perianal diseases, suggesting certain sleep disorders contribute to hemorrhoidal disease. Furthermore, incorporating sleep interventions into perianal disease management offers potential benefits warranting further investigation.
Sleep Traits / Perianal Diseases / Genetic Insight / Bidirectional Analysis
The Author(s) 2026.
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