Faecal microbiota transplant revisited - potential metabolic outcomes of regional microbiome mismatches

Elisabeth A. A. O’Flaherty , Douwe van Sinderen

Microbiome Research Reports ›› 2026, Vol. 5 ›› Issue (3) : 24

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Microbiome Research Reports ›› 2026, Vol. 5 ›› Issue (3) :24 DOI: 10.20517/mrr.2026.29
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Faecal microbiota transplant revisited - potential metabolic outcomes of regional microbiome mismatches
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Elisabeth A. A. O’Flaherty, Douwe van Sinderen. Faecal microbiota transplant revisited - potential metabolic outcomes of regional microbiome mismatches. Microbiome Research Reports, 2026, 5 (3) : 24 DOI:10.20517/mrr.2026.29

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References

[1]

DeFilipp Z,Torres Soto M.Drug-resistant E. Coli bacteremia transmitted by fecal microbiota transplant.N Engl J Med2019;381:2043-50

[2]

Baxter M,Colville A.Fatal aspiration pneumonia as a complication of fecal microbiota transplant.Clin Infect Dis2015;61:136-7

[3]

Cymbal M,Baggott B.Fecal microbiota transplantation: current evidence and future directions.Cleve Clin J Med2025;92:421-8

[4]

Khanna S,Lee C.Efficacy and safety of RBX2660 in PUNCH CD3, a Phase III, randomized, double-blind, placebo-controlled trial with a Bayesian primary analysis for the prevention of recurrent Clostridioides difficile infection.Drugs2022;82:1527-38 PMCID:PMC9607700

[5]

Feuerstadt P,Lashner B.SER-109, an oral microbiome therapy for recurrent clostridioides difficile infection.N Engl J Med2022;386:220-9

[6]

Bethlehem L,Marke G.15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial.Nat Med2026;32:2546-55 PMCID:PMC13444918

[7]

Davar D,McCulloch JA.Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients.Science2021;371:595-602 PMCID:PMC8097968

[8]

Kootte RS,Salojärvi J.Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition.Cell Metab2017;26:611-619.e6

[9]

Zhang F,Wan Y.Multi-omic analyses identify mucosa bacteria and fecal metabolites associated with weight loss after fecal microbiota transplantation.Innovation (Camb)2022;3:100304 PMCID:PMC9460156

[10]

Zhang J,Wan L.Effect of fecal microbiota transplantation in children with autism spectrum disorder: a systematic review.Front Psychiatry2023;14:1123658 PMCID:PMC10017995

[11]

Leong KSW,Wilson BC.Effects of fecal microbiome transfer in adolescents with obesity: the gut bugs randomized controlled trial.JAMA Netw Open2020;3:e2030415 PMCID:PMC7753902

[12]

Recasens-Alvarez C,Green G.The evolution of the obesity drug market.Nat Rev Drug Discov2025;24:902-3

[13]

DeLeon O,Tan A.Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects.Cell2025;188:3927-3941.e13 PMCID:PMC12330209

[14]

Shalon D,Grembi JA.Profiling the human intestinal environment under physiological conditions.Nature2023;617:581-91 PMCID:PMC10191855

[15]

She JJ,Ding XM.Defining the biogeographical map and potential bacterial translocation of microbiome in human ‘surface organs’.Nat Commun2024;15:427 PMCID:PMC10781665

[16]

Mullish BH,Williams HRT.Microbiota transplants: the concept of 'microbiome mismatching' explored.Signal Transduct Target Ther2025;10:374 PMCID:PMC12620514

[17]

Toit AD.A misplaced microbiome.Nat Rev Microbiol2025;23:472

[18]

Ridaura VK,Rey FE.Gut microbiota from twins discordant for obesity modulate metabolism in mice.Science2013;341:1241214 PMCID:PMC3829625

[19]

Feng J,Zhu H.Early diabetes-like phenotypes in germ-free mice induced by gut microbiota from patients with type 2 diabetes.Animal Model Exp Med2026;9:1202-16 PMCID:PMC13383894

[20]

Lefebvre P,Baugé E.Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.JCI Insight2017;2:92264 PMCID:PMC5499370

[21]

Mi F,Zheng W,Ye H.Fecal microbiota transplantation alleviates steatosis and inflammation in high-fat and high-sugar diet-induced fatty liver in mice.Front Cell Dev Biol2026;14:1723128 PMCID:PMC12979525

[22]

Wang H,Wang M.Integrated proteomics and metabolomics reveal the direct hepatic protection of propionate against alcoholic liver disease via the RGN-PPARα Pathway.Nutrients2026;18:872 PMCID:PMC12987040

[23]

Yang G,Hu Y.The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study.Biomark Res2023;11:20 PMCID:PMC9938992

[24]

Psichas A,Murphy KG.The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents.Int J Obes (Lond)2015;39:424-9 PMCID:PMC4356745

[25]

Perino A,Bresciani N.Central anorexigenic actions of bile acids are mediated by TGR5.Nat Metab2021;3:595-603 PMCID:PMC7610881

[26]

Kuhre RE,Larsen O.Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.Mol Metab2018;11:84-95 PMCID:PMC6001409

[27]

Chambers ES,Morrison DJ.Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.Gut2019;68:1430-8 PMCID:PMC6691855

[28]

Batterham RL,Small CJ.Gut hormone PYY(3-36) physiologically inhibits food intake.Nature2002;418:650-4

[29]

Rangwala SM,Zhang YM.A long-acting PYY(3-36) analog mediates robust anorectic efficacy with minimal emesis in nonhuman primates.Cell Metab2019;29:837-843.e5 PMCID:PMC6701930

[30]

Turton MD,Gunn I.A role for glucagon-like peptide-1 in the central regulation of feeding.Nature1996;379:69-72

[31]

Zander M,Madsen JL.Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study.Lancet2002;359:824-30

[32]

Alang N.Weight gain after fecal microbiota transplantation.Open Forum Infect Dis2015;2:ofv004 PMCID:PMC4438885

[33]

Paramsothy S,Kamm MA.Specific bacteria and metabolites associated with response to fecal microbiota transplantation in patients with ulcerative colitis.Gastroenterology2019;156:1440-1454.e2

[34]

Martinez-Gili L,Liu Z.Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites.Gut Microbes2020;12:1810531 PMCID:PMC7524310

[35]

Chen Y,Jiaqu C.Fecal microbiota and human intestinal fluid transplantation: methodologies and outlook.Front Med (Lausanne)2022;9:830004 PMCID:PMC9158325

[36]

Pastor B, Shkoporov AN, Hill C. Not just passengers: phages as agents of genetic exchange in fecal microbiota transplantation.Cell Host Microbe2026;34:780-9

[37]

Draper LA,Smith MK.Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation.Microbiome2018;6:220 PMCID:PMC6288847

[38]

Zuppi M,Wilson BC.Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity.Microbiome2024;12:122 PMCID:PMC11227244

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