We need to talk about the virome

Colin Hill

Microbiome Research Reports ›› 2026, Vol. 5 ›› Issue (2) : 16

PDF
Microbiome Research Reports ›› 2026, Vol. 5 ›› Issue (2) :16 DOI: 10.20517/mrr.2026.13
Commentary
We need to talk about the virome
Author information +
History +
PDF

Cite this article

Download citation ▾
Colin Hill. We need to talk about the virome. Microbiome Research Reports, 2026, 5 (2) : 16 DOI:10.20517/mrr.2026.13

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Shkoporov AN,Hill C. Bacteriophages of the human gut: the “known unknown” of the microbiome Cell Host Microbe. 2019 25 195 209

[2]

Pargin E,Roach MJ,Skye A.et al. The human gut virome: composition, colonization, interactions, and impacts on human health Front. Microbiol. 2023 14 963173 PMC10244655

[3]

Dutilh BE,Cassman N,Mcnair K.et al. A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes Nat Commun. 2014 5 4498 PMC4111155

[4]

Guerin E,Shkoporov A,Stockdale SR.et al. Biology and taxonomy of crAss-like bacteriophages, the most abundant virus in the human gut Cell Host Microbe. 2018 24 653 664.e6

[5]

Bin Jang H,Bolduc B,Zablocki O.et al. Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks Nat Biotechnol. 2019 37 632 9

[6]

Bolduc B,Zablocki O,Turner D.et al. Machine learning enables scalable and systematic hierarchical virus taxonomy Nat Biotechnol. 2025 2946

[7]

Yang F,Xiong L,Li M.et al. A signature-protein-based approach for accurate and efficient profiling of the human gut virome Cell Rep Methods. 2026 6 101250 PMC12853188

[8]

Liu H,Shen J,Zhang Z.et al. Exploring functional insights into the human gut microbiome via the structural proteome Cell Host Microbe. 2026 34 167 185.e9

[9]

Tal N,Hadary R,Chang RB.et al. Structural modeling reveals phage proteins that manipulate bacterial immune signaling Science. 2026 391 eaea1761

[10]

Shkoporov AN,Stockdale SR,Lavelle A.et al. Viral biogeography of the mammalian gut and parenchymal organs Nat Microbiol. 2022 7 1301 11 PMC7614033

[11]

Shkoporov AN,Clooney AG,Sutton TD.et al. The human gut virome is highly diverse, stable, and individual specific Cell Host Microbe. 2019 26 527 541.e5

[12]

Shkoporov AN,Khokhlova EV,Fitzgerald CB.et al. ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis Nat Commun. 2018 9 4781 PMC6235969

[13]

Bayfield OW,Shkoporov AN,Yutin N.et al. Structural atlas of a human gut crassvirus Nature. 2023 617 409 16 PMC10172136

[14]

Shkoporov AN,Khokhlova EV,Stephens N.et al. Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis BMC Biol. 2021 19 163 PMC8375218

[15]

Cortés-Martín A,Buttimer C,Maier JL.et al. Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages Gut Microbes. 2025 17 2507775 PMC12118408

[16]

Porter NT,Canales P,Peterson DA,Martens EC. A subset of polysaccharide capsules in the human symbiont Bacteroides thetaiotaomicron promote increased competitive fitness in the mouse gut Cell Host Microbe. 2017 22 494 506.e8 PMC5830307

[17]

Borodovich T,Shkoporov AN,Ross RP,Hill C. Phage-mediated horizontal gene transfer and its implications for the human gut microbiome Gastroenterol Rep. 2022 10 goac012 PMC9006064

[18]

Borodovich T,Buttimer C,Wilson JS.et al. Large-scale capsid-mediated mobilisation of bacterial genomic DNA in the gut microbiome Nat Commun. 2026 17 2046 PMC12946183

[19]

Nethery MA,Hidalgo-Cantabrana C,Roberts A,Barrangou R. CRISPR-based engineering of phages for in situ bacterial base editing Proc Natl Acad Sci USA. 2022 119 e2206744119 PMC9674246

PDF

0

Accesses

0

Citation

Detail

Sections
Recommended

/