Milk matters: seeding gut ecosystems and shaping microbiota rivalries

Laura Noël-Romas; Kelsey Fehr; Saeid Khakisahneh; Meghan B. Azad

doi:10.20517/mrr.2024.91

Microbiome Research Reports ›› 2025, Vol. 4 ›› Issue (2) :17 DOI: 10.20517/mrr.2024.91

Research Highlight

Milk matters: seeding gut ecosystems and shaping microbiota rivalries

Author information +

History +

PDF

Abstract

Maternal milk contains its own diverse microbiome, which has been hypothesized to colonize the infant gut during breastfeeding; however, the dynamics of this process are not well understood, particularly among very-low-birth-weight (VLBW) infants. A recent study published in Cell Reports Medicine by Shama et al. identifies novel dose-dependent relationships between maternal milk microbiota and infant gut microbiota in a cohort of VLBW infants and further explores the potential impact of infant feeding practices and antibiotic use on these microbial colonization dynamics.

Keywords

Breastfeeding / human milk / microbiome / very-low-birth-weight infants / antibiotics

Cite this article

Download citation ▾

Laura Noël-Romas, Kelsey Fehr, Saeid Khakisahneh, Meghan B. Azad. Milk matters: seeding gut ecosystems and shaping microbiota rivalries. Microbiome Research Reports, 2025, 4(2): 17 DOI:10.20517/mrr.2024.91

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Shama S, Asbury MR, Kiss A, et al; OptiMoM Feeding Group. Mother’s milk microbiota is associated with the developing gut microbial consortia in very-low-birth-weight infants. Cell Rep Med 2024;5:101729. PMCID:PMC11525026

[2]	World Health Organization & United Nations Children’s Fund (UNICEF). Protecting, promoting and supporting breastfeeding: the baby-friendly hospital initiative for small, sick and preterm newborns. 2020. https://iris.who.int/handle/10665/333686. (accessed on 12 Mar 2025)

[3]	Ma J,Geddes D,Stinson L.Human milk microbiome and microbiome-related products: potential modulators of infant growth.Nutrients2022;14:5148 PMCID:PMC9737635

[4]	Bode L,Murch SH,Gordon JI.Understanding the mother-breastmilk-infant “triad”.Science2020;367:1070-2

[5]	O’Connor DL, Kiss A, Tomlinson C, et al; OptiMoM Feeding Group. Nutrient enrichment of human milk with human and bovine milk-based fortifiers for infants born weighing < 1250 g: a randomized clinical trial. Am J Clin Nutr 2018;108:108-16.

[6]	Davis EC,Sela DA.Gut microbiome and breast-feeding: implications for early immune development.J Allergy Clin Immunol2022;150:523-34 PMCID:PMC9463492

[7]	Fehr K,Sbihi H.Breastmilk feeding practices are associated with the co-occurrence of bacteria in mothers’ milk and the infant gut: the CHILD cohort study.Cell Host Microbe2020;28:285-97.e4