RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi

Yanfei Du , Daohong Jiang , Huiquan Liu

mLife ›› 2025, Vol. 4 ›› Issue (6) : 597 -601.

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mLife ›› 2025, Vol. 4 ›› Issue (6) :597 -601. DOI: 10.1002/mlf2.70057
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RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi
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altruism / antiviral defense / fitness trade-offs / OLD-ZAO / RNA editing

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Yanfei Du, Daohong Jiang, Huiquan Liu. RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi. mLife, 2025, 4(6): 597-601 DOI:10.1002/mlf2.70057

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References

[1]

Lukeš J, Kaur B, Speijer D. RNA editing in mitochondria and plastids: weird and widespread. Trends Genet. 2021; 37: 99–102.

[2]

Chateigner-Boutin AL, Small I. Organellar RNA editing. WIREs RNA. 2011; 2: 493–506.

[3]

Xin K, Kang X, Liu M, Fan J, Du Y, Feng C, et al. Navigating trade-offs: the adaptive significance of A-to-I RNA editing in fungi, bacteria, and animals. Epigenetics Insights. 2025; 18:e002.

[4]

Qi Z, Lu P, Long X, Cao X, Wu M, Xin K, et al. Adaptive advantages of restorative RNA editing in fungi for resolving survival-reproduction trade-offs. Sci Adv. 2024; 10:eadk6130.

[5]

Eisenberg E, Levanon EY. A-to-I RNA editing – immune protector and transcriptome diversifier. Nat Rev Genet. 2018; 19: 473–490.

[6]

Zhang P, Zhu Y, Guo Q, Li J, Zhan X, Yu H, et al. On the origin and evolution of RNA editing in metazoans. Cell Rep. 2023; 42:112112.

[7]

Bian Z, Ni Y, Xu JR, Liu H. A-to-I mRNA editing in fungi: occurrence, function, and evolution. Cell Mol Life Sci. 2019; 76: 329–340.

[8]

Liu H, Wang Q, He Y, Chen L, Hao C, Jiang C, et al. Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes. Genome Res. 2016; 26: 499–509.

[9]

Feng C, Xin K, Du Y, Zou J, Xing X, Xiu Q, et al. Unveiling the A-to-I mRNA editing machinery and its regulation and evolution in fungi. Nat Commun. 2024; 15: 3934.

[10]

Du Y, Wang C, Zhang Y, Liu H. Evolutionary origins and adaptive significance of A-to-I RNA editing in animals and fungi. BioEssays. 2025; 47:e202400220.

[11]

Honda S, Yokoyama A, Suzuki N. RNA editing of genomic neighbors controls antiviral response in fungi. Cell Host Microbe. 2025; 33: 545–559.

[12]

Iyer LM, Zhang D, Rogozin IB, Aravind L. Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems. Nucleic Acids Res. 2011; 39: 9473–9497.

[13]

Zou J, Du Y, Xing X, Huang P, Wang Z, Liu H, et al. Hyphal editing of the conserved premature stop codon in CHE1 is stimulated by oxidative stress in Fusarium graminearum. Stress Biology. 2024; 4: 30.

[14]

Jiang D, Zhang J. The preponderance of nonsynonymous A-to-I RNA editing in coleoids is nonadaptive. Nat Commun. 2019; 10: 5411.

[15]

Honda S, Eusebio-Cope A, Miyashita S, Yokoyama A, Aulia A, Shahi S, et al. Establishment of Neurospora crassa as a model organism for fungal virology. Nat Commun. 2020; 11: 5627.

[16]

Xie J, Jiang D. Understanding the diversity, evolution, ecology, and applications of mycoviruses. Annu Rev Microbiol. 2024; 78: 595–620.

[17]

Hamilton WD. The genetical evolution of social behaviour. I. J Theor Biol. 1964; 7: 1–16.

[18]

Gonçalves AP, Heller J, Rico-Ramírez AM, Daskalov A, Rosenfield G, Glass NL. Conflict, competition, and cooperation regulate social interactions in filamentous fungi. Annu Rev Microbiol. 2020; 74: 693–712.

[19]

Kay T, Keller L, Lehmann L. The evolution of altruism and the serial rediscovery of the role of relatedness. Proc Natl Acad Sci USA. 2020; 117: 28894–28898.

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2025 The Author(s). mLife published by John Wiley & Sons Australia, Ltd on behalf of Institute of Microbiology, Chinese Academy of Sciences.

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