GTP cycling protein (GCP): An ancient player for allosteric gatekeeping

mLife ›› 2025, Vol. 4 ›› Issue (5) :511 -515. DOI: 10.1002/mlf2.70043

OPINION

Author information +

History +

PDF

Download citation ▾

Ji-Long Liu. GTP cycling protein (GCP): An ancient player for allosteric gatekeeping. mLife, 2025, 4(5): 511-515 DOI:10.1002/mlf2.70043

登录浏览全文

4963

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	McCormick F. GTP binding and growth control. Curr Opin Cell Biol. 1990; 2: 181–184.

[2]	Mrnjavac N, Martin WF. GTP before ATP: the energy currency at the origin of genes. Biochim Biophys Acta Bioenerg. 2025; 1866:149514.

[3]	Hall A. Signal transduction through small GTPases--a tale of two GAPs. Cell. 1992; 69: 389–391.

[4]	Guo CJ, Wu YF, Guo SY, Lu JL, Xu L, Fu Y, et al. GTP cycling gates CTP synthase activation. bioRxiv. 2022. https://doi.org/10.1101/2022.09.24.509316

[5]	Zhou X, Guo CJ, Chang CC, Zhong J, Hu HH, Lu GM, et al. Structural basis for ligand binding modes of CTP synthase. Proc Natl Acad Sci USA. 2021; 118:e2026621118.

[6]	Bearne SL, Guo CJ, Liu JL. GTP-dependent regulation of CTP synthase: evolving insights into allosteric activation and NH₃ translocation. Biomolecules. 2022; 12:647.

[7]	Liu JL. Intracellular compartmentation of CTP synthase in Drosophila. J Genet Genomics. 2010; 37: 281–296.

[8]	Liu JL. The enigmatic cytoophidium: compartmentation of CTP synthase via filament formation. BioEssays. 2011; 33: 159–164.

[9]	Liu JL. The Cytoophidium and its kind: filamentation and compartmentation of metabolic enzymes. Annu Rev Cell Dev Biol. 2016; 32: 349–372.

[10]	Ingerson-Mahar M, Briegel A, Werner JN, Jensen GJ, Gitai Z. The metabolic enzyme CTP synthase forms cytoskeletal filaments. Nat Cell Biol. 2010; 12: 739–746.

[11]	Noree C, Sato BK, Broyer RM, Wilhelm JE. Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster. J Cell Biol. 2010; 190: 541–551.

[12]	Marshall CJ. The ras oncogenes. J Cell Sci. 1988; 1988: 157–169.

[13]	Guo C, Wang Z, Liu JL. Filamentation and inhibition of prokaryotic CTP synthase with ligands. mLife. 2024; 3: 240–250.

[14]	Cameron TA, Margolin W. Insights into the assembly and regulation of the bacterial divisome. Nat Rev Microbiol. 2024; 22: 33–45.

[15]	Katagiri D, Hata M, Itoh T, Neya S, Hoshino T. Atomic-scale mechanism of the GTP → GDP hydrolysis reaction by the Giα1 protein. J Phys Chem B. 2003; 107: 3278–3283.

[16]	MacDonnell J. Inhibition of E. coli CTP synthase by the “positive” allosteric effector GTP. Biochim Biophys Acta. 2004; 1699: 213–220.

[17]	Lunn FA, MacDonnell JE, Bearne SL. Structural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are lax. J Biol Chem. 2008; 283: 2010–2020.

[18]	Buhrman G, Holzapfel G, Fetics S, Mattos C. Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc Natl Acad Sci USA. 2010; 107: 4931–4936.