Metal-organic frameworks-based nanomedicines to promote cancer immunotherapy: Recent advances and future directions

Abstract

Cancer immunotherapy uses the body’s immune system to fight tumors by restoring natural antitumor responses. Metal-organic frameworks (MOFs), characterized by their unique crystalline porous structures formed from metal ions linked by organic ligands, offer a promising solution. Recent studies have unveiled the potential of MOFs in cancer immunotherapy. The exceptional porosity and surface area, coupled with their extraordinary thermal and chemical stability, bring significant advantages for efficient drug loading and delivery of immunotherapeutic agents. The adaptability of MOFs further enhances the controlled release of immunotherapeutic drugs within target cells and increases tumor sensitivity to other therapies such as photodynamic, photothermal, and radiotherapy. This multifunctional carrier contributes to modulating the tumor microenvironment and reactivating antitumor immunity, providing a comprehensive strategy for cancer treatment. In this review, we summarize the applications of MOFs in immune checkpoint blockade, immunomodulator delivery, and cancer vaccine delivery, and discuss existing challenges in their use for immunotherapy. This discussion aims to offer insights for developing better treatments and enhancing the efficacy of immunotherapy.

Keywords

immunogenic cell death / immunotherapy / metal-organic frameworks / nanoparticle

References

[1] SungH, FerlayJ, SiegelRL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249.

[2] WangC, LiuZ. Mineralized bacteria as an immunotherapy agent against various cancer types. Nat Biomed Eng. 2024;8:497-498.

[3] EggermontAMM, Chiarion-Sileni V, GrobJJ, et al. Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N Engl J Med. 2016;375(19):1845-1855.

[4] XiaY, LiX, BieN, et al. A method for predicting drugs that can boost the efficacy of immune checkpoint blockade. Nature Immunol. 2024;25(4):659-670.

[5] NichakawadeTD, GeJ, MogBJ, et al. TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers. Nature. 2024;628(8007):416-423.

[6] SuijkerbuijkKPM, van Eijs MJM, van WijkF, EggermontAMM. Clinical and translational attributes of immune-related adverse events. Nature Cancer. 2024;5:557-571.

[7] HerbstRS, SoriaJC, KowanetzM, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515(7528):563-567.

[8] OsterriethJWM, Fairen-Jimenez D. Metal-organic framework composites for theragnostics and drug delivery applications. Biotechnol J. 2021;16(2):2000005.

[9] BoR, TaheriM, LiuB, et al. Hierarchical metal-organic framework films with controllable meso/macroporosity. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2020;7(24):2002368.

[10] AnQ, XuZ, ShangW, et al. Polyoxometalate-based metal-organic frameworks as the solid support to immobilize MP-11 enzyme for enhancing thermal and recyclable stability. ACS Appl Bio Mater. 2022;5(3):1222-1229.

[11] WangS, LyHGT, WahiduzzamanM, et al. A zirconium metal-organic framework with SOC topological net for catalytic peptide bond hydrolysis. Nat Commun. 2022;13(1):1284.

[12] MaL, JiangF, FanX, et al. Metal-organic-framework-engineered enzyme-mimetic catalysts. Adv Mater. 2020;32(49):2003065.

[13] ZhangW, YeG, LiaoD, et al. Recent advances of silver-based coordination polymers on antibacterial applications. Molecules. 2022;27(21):7166.

[14] LiL, ZouJ, HanY, et al. Recent advances in Al(iii)/In(iii)-based MOFs for the detection of pollutants. New J Chem. 2022;46(41):19577-19592.

[15] SheikhsamanyR, Nezamzadeh-Ejhieh A, EnsandoostR, KakavandiB. BaTi_0.85Zr_0.15O₃/MOF-5 nanocomposite: synthesis, characterization and photocatalytic activity toward tetracycline. J Mol Liq. 2024;403:124850.

[16] YuY, ZhangJ, HuangW, Luo L, HanL, SunT. Spatiotemporally controlled AuNPs@ZIF-8 based nanocarriers for synergistic photothermal/chemodynamic therapy. Article Acta Biomater. 2024;175:317-328.

[17] ChenB, FanD, PintoRV, et al. A scalable robust microporous AI-MOF for post-combustion carbon capture. Adv Sci. 2024;11(21):2401070.

[18] ZhaoY, WuS, WangJ, et al. A stable extra-large pore and high-silica zeolite derived from ge-rich precursor. Angew Chem Int Ed. 2024;63(10):202318298.

[19] ChenX, Argandona SM, MelleF, RampalN, Fairen-Jimenez D. Advances in surface functionalization of nextgeneration metal-organic frameworks for biomedical applications: design, strategies, and prospects. Chemistry. 2024;10(2):504-543.

[20] ChuC, SuM, ZhuJ, et al. Metal-organic framework nanoparticle-based biomineralization: a new strategy toward cancer treatment. Theranostics. 2019;9(11):3134-3149.

[21] ChenJ, ChengF, LuoD, et al. Recent advances in Ti-based MOFs in biomedical applications. Dalton Trans. 2022;51(39):14817-14832.

[22] DurmusC, ArulP, AlhajiA, et al. Metal-organic frameworks modified electrode for H₂S detections in biological and pharmaceutical agents. MedComm - Biomater Appl. 2023;2:e57.

[23] ChengR, JiangL, GaoH, et al. A pH-responsive cluster metal-organic framework nanoparticle for enhanced tumor accumulation and antitumor effect. Adv Mater Deerfield. 2022;34(42):2203915.

[24] ChenX, MendesBB, ZhuangY, et al. A fluorinated BODIPY-based zirconium metal-organic framework for in vivo enhanced photodynamic therapy. J Am Chem Soc. 2024;146(2):1644-1656.

[25] ZengY, XuG, KongX, et al. Recent advances of the core-shell MOFs in tumour therapy. Int J Pharm. 2022;627:122228.

[26] MaJ, ChenZ, DiaoY, et al. Current and promising applications of UiO-based MOFs in breast cancer therapy. React Funct Polym. 2024;200:105918.

[27] LinZ, LiaoD, JiangC, et al. Current status and prospects of MIL-based MOF materials for biomedicine applications. Rsc Med Chem. 2023;14(10):1914-1933.

[28] SinghN, QutubS, KhashabNM. Biocompatibility and biodegradability of metal organic frameworks for biomedical applications. J Mater Chem B. 2021;9(30):5925-5934.

[29] AlsaiariSK, QutubSS, SunS, et al. Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy. Sci Adv. 2021;7(4):eabe7174.

[30] GeYX, ZhangTW, ZhouL, et al. Enhancement of anti-PD-1/PD-L1 immunotherapy for osteosarcoma using an intelligent autophagy-controlling metal organic framework. Biomaterials. 2022;282:121407.

[31] JiangS, LiuC, HeQ, DangK, ZhangW, Tian Y. Porphyrin-based metal-organic framework nanocrystals for combination of immune and sonodynamic therapy. Nano Res. 2023;16(7):9633-9641.

[32] BaiXF, ChenY, ZouMZ, et al. Homotypic targeted photosensitive nanointerferer for tumor cell cycle arrest to boost tumor photoimmunotherapy. ACS Nano. 2022;16(11):18555-18567.

[33] ZhangJ, ChenC, LiA, et al. Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection. Nat Nanotechnol. 2021;16(5):538-548.

[34] DuL, HeH, XiaoZ, et al. GSH-responsive metal-organic framework for intratumoral release of NO and IDO inhibitor to enhance antitumor immunotherapy. Article Small. 2022;18(15):2107732.

[35] FanQ, ZuoJ, TianH, et al. Nanoengineering a metal-organic framework for osteosarcoma chemo-immunotherapy by modulating indoleamine-2, 3-dioxygenase and myeloid-derived suppressor cells. J Exp Clin Cancer Res. 2022;41(1):162.

[36] DingY, SunZ, GaoY, et al. Plasmon-driven catalytic chemotherapy augments cancer immunotherapy through induction of immunogenic cell death and blockage of IDO pathway. Adv Mater. 2021;33(34):2102188.

[37] DingB, ChenH, TanJ, et al. ZIF-8 nanoparticles evoke pyroptosis for high-efficiency cancer immunotherapy. Angew Chem Int Ed. 2023;62(10):202215307.

[38] ZhangH, ZhangJ, LiQ, et al. Site-specific MOF-based immunotherapeutic nanoplatforms via synergistic tumor cells-targeted treatment and dendritic cells-targeted immunomodulation. Biomaterials. 2020;245:119983.

[39] ZhaoQ, GongZ, LiZ, et al. Target reprogramming lysosomes of CD8⁺T cells by a mineralized metal-organic framework for cancer immunotherapy. Article Adv Mater. 2021;33(17):2100616.

[40] FanZ, LiuH, XueY, et al. Reversing cold tumors to hot: an immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy. Bioactive Mater. 2021;6(2):312-325.

[41] WeiZ, ZhangX, ZhangZ, et al. Engineered iron-based nanoplatform amplifies repolarization of M2-like tumor-associated macrophages for enhanced cancer immunotherapy. Chem Eng J. 2022;433:133847.

[42] NiK, LuoT, CulbertA, Kaufmann M, JiangX, LinW. Nanoscale metal-organic framework co-delivers TLR-7 agonists and anti-CD47 antibodies to modulate macrophages and orchestrate cancer immunotherapy. J Am Chem Soc. 2020;142(29):12579-12584.

[43] ChenX, TangQ, WangJ, et al. A DNA/DMXAA/metal-organic framework activator of innate immunity for boosting anticancer immunity. Adv Mater. 2023;35(15):2210440.

[44] DaiZ, WangQ, TangJ, et al. Immune-regulating bimetallic metal-organic framework nanoparticles designed for cancer immunotherapy. Biomaterials. 2022;280:121261.

[45] YangH, ZhangY, ZengL, et al. Cell-selective encapsulation within metal-organic framework shells via precursor-functionalized aptamer identification for whole-cell cancer vaccine. Article Small Methods. 2022;6(3):2101391.

[46] ZhongX, ZhangY, TanL, et al. An aluminum adjuvant-integrated nano-MOF as antigen delivery system to induce strong humoral and cellular immune responses. J Controlled Release. 2019;300:81-92.

[47] NiK, LanG, GuoN, et al. Nanoscale metal-organic frameworks for x-ray activated in situ cancer vaccination. Sci Adv. 2020;6(40):eabb5223.

[48] YalamandalaBN, HuynhTMH, ChiangMR, et al. Programmed catalytic therapy and antigen capture-mediated dendritic cells harnessing cancer immunotherapies by in situ-forming adhesive nanoreservoirs. Adv Funct Mater. 2022;33(15):2210644.

[49] GaoS, ZhengP, LiZ, et al. Biomimetic O₂-evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor. Biomaterials. 2018;178:83-94.

[50] MaY, SuZ, ZhouL, et al. Biodegradable metal-organic-framework-gated organosilica for tumor-microenvironment-unlocked glutathione-depletion-enhanced synergistic therapy. Adv Mater. 2022;34(12):2107560.

[51] YinS-Y, SongG, YangY, et al. Persistent regulation of tumor microenvironment via circulating catalysis of MnFe₂O₄@metal-organic frameworks for enhanced photodynamic therapy. Adv Funct Mater. 2019;29(25):1901417.

[52] QuailDF, JoyceJA. Microenvironmental regulation of tumor progression and metastasis. Nature Med. 2013;19(11):1423-1437.

[53] ShirotaY, Shirota H, KlinmanDM. Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells. J Immunol. 2012;188(4):1592-1599.

[54] TalmadgeJE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer. 2013;13(10):739-752.

[55] ChenQ, HeY, WangY, et al. Penetrable nanoplatform for “cold” tumor immune microenvironment reeducation. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2020;7(17):2000411.

[56] AlsaabHO, SauS, AlzhraniR, et al. PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome. Front Pharmacol. 2017;8:561.

[57] RileyRS, JuneCH, LangerR, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discovery. 2019;18(3):175-196.

[58] GuanB, ZhangL, YuS. Acute coronary syndrome in a patient with gastric cancer treated by immune checkpointinhibitor: a case report. Malig Spect. 2024;1:5.

[59] MalekiA, Shahbazi M-A, AlinezhadV, SantosHA. The progress and prospect of zeolitic imidazolate frameworks in cancer therapy, antibacterial activity, and biomineralization. Adv Healthcare Mater. 2020;9(12):2000248.

[60] LiW, MaT, HeT, LiY, YinS. Cancer cell membrane-encapsulated biomimetic nanoparticles for tumor immuno-photothermal therapy. Chem Eng J. 2023;463:142495.

[61] MullerAJ, DuHadaway JB, DonoverPS, Sutanto-WardE, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nature Med. 2005;11(3):312-319.

[62] LadomerskyE, ZhaiL, LenzenA, et al. IDO1 inhibition synergizes with radiation and PD-1 blockade to durably increase survival against advanced glioblastoma. Clin Cancer Res. 2018;24(11):2559-2573.

[63] ZhangL, XuL, WangY, et al. A novel therapeutic vaccine based on graphene oxide nanocomposite for tumor immunotherapy. Chin Chem Lett. 2022;33(8):4089-4095.

[64] SadikA, Somarribas Patterson LF, ÖztürkS, et al. IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression. Cell. 2020;182(5):1252-1270.e34.

[65] QinQ, WangM, ZouY, et al. Development of nanoparticle-based drug delivery system for inflammation treatment and diagnosis. MedComm - Biomater Appl. 2023;2:e65.

[66] KumarS, ShuklaMK, SharmaAK, et al. Metal-based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy. Medcomm. 2023;4(2):e253.

[67] ZhangY, WangT, ZhangJ, et al. Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chin Chem Lett. 2024;35(4):108619.

[68] SunL, GaoH, WangH, et al. Nanoscale metal-organic frameworks-mediated degradation of mutant p53 proteins and activation of cGAS-STING pathway for enhanced cancer immunotherapy. Adv Sci. 2024;11(12):2307278.

[69] CuiH, ZhaoY-Y, WuQ, et al. Microwave-responsive gadolinium metal-organic frameworks nanosystem for MRI-guided cancer thermotherapy and synergistic immunotherapy. Article Bioactive Materials. 2024;33:532-544.

[70] DuJ, JiaT, LiF, et al. MOF-coated upconversion nanoparticle agents enable synergistic photodynamic therapy and immunotherapy. Adv Funct Mater. 2024;2401272.

[71] WijesundaraYH, Howlett TS, KumariS, GassensmithJJ. The promise and potential of metal-organic frameworks and covalent organic frameworks in vaccine nanotechnology. Chem Rev. 2024;124(6):3013-3036.

[72] ChenZ, WangX, ZhaoN, Chen H, GuoG. Advancements in ph-responsive nanocarriers: enhancing drug delivery for tumor therapy. Expert Opin Drug Delivery. 2023;20(11):1623-1642.

[73] SwidanMM, WahbaNS, SakrTM. An intelligent and self-assembled nanoscale metal organic framework (^99mTC-DOX loaded Fe₃O₄@Fe^III-tannic acid) for tumor targeted chemo/chemodynamic theranostics. Cancer Nanotechnol. 2024;15(1):28.

[74] FanR, ChenC, MuM, et al. Engineering MMP-2 activated nanoparticles carrying B7-H3 bispecific antibodies for ferroptosis-enhanced glioblastoma immunotherapy. ACS Nano. 2023;17(10):9126-9139.

[75] ChuanD, FanR, ChenB, et al. Lipid-polymer hybrid nanoparticles with both PD-L1 knockdown and mild photothermal effect for tumor photothermal immunotherapy. Article ACS Appl Mater Interfaces. 2023;15(36):42209-42226.

[76] FengC, ChenB, FanR, ZouB, HanB, GuoG. Polyphenol-based nanosystems for next-generation cancer therapy: multifunctionality, design, and challenges. Review Macromol Biosci. 2023;23(11):2300167.

[77] GuoZ, JinB, FangY, et al. Automated screening of primary cell-based aptamers for targeting and therapy of pancreatic cancer. Chin Chem Lett. 2024;35(2):108528.

[78] ZhangT, ShiH, ZhangS, et al. FGF21 increases the sensitivity of hepatocellular carcinoma to sorafenib under hypoxia. Malig Spect. 2024;1(2):99-112.

[79] ZhangX, JiL, LiMO. Control of tumor-associated macrophage responses by nutrient acquisition and metabolism. Immunity. 2023;56(1):14-31.

[80] LiangX, MuM, FanR, ZouB, GuoG. Functionalized chitosan as a promising platform for cancer immunotherapy: a review. Carbohydr Polymers. 2022;290:119452.

[81] KloostermanDJ, AkkariL. Macrophages at the interface of the co-evolving cancer ecosystem. Cell. 2023;186(8):1627-1651.

[82] MurrayPJ. Macrophage polarization. In: Julius D, ed. Annu Rev Physiol. 2017;79:541-566.

[83] VitaleI, ManicG, CoussensLM, Kroemer G, GalluzziL. Macrophages and metabolism in the tumor microenvironment. Cell Metab. 2019;30(1):36-50.

[84] PanS, FanR, HanB, TongA, GuoG. The potential of mRNA vaccines in cancer nanomedicine and immunotherapy. Trends Immunol. 2024;45(1):20-31.

[85] ChenW, YangM, WangH, et al. A novel CaCu-metal-organic-framework based multimodal treatment platform for enhanced synergistic therapy of hepatocellular carcinoma. Adv Healthcare Mater. 2024;13(17):2304000.

[86] LiuF, TanL, DaiZ, et al. Manganese-based microcrystals equipped with YTHDF1-targeted biomimetic nanovaccines for reinforced dendritic cell spatiotemporal orchestration. Article Nano Today. 2024;54:102112.

[87] ZhangL, Montesdeoca N, KargesJ, XiaoH. Immunogenic cell death inducing metal complexes for cancer therapy. Angew Chem Int Ed. 2023;62(21):202300662.

[88] MeierP, Legrand AJ, AdamD, SilkeJ. Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nat Rev Cancer. 2024;24(5):299-315.

[89] NiK, XuZ, CulbertA, et al. Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework. Nat Biomed Eng. 2022;6(2):144-156.

[90] SunM, LiuZ, WuL, YangJ, RenJ, QuX. Bioorthogonal-activated in situ vaccine mediated by a COF-based catalytic platform for potent cancer immunotherapy. J Am Chem Soc. 2023;145(9):5330-5341.

[91] ZhangL, SongA, YangQC, et al. Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy. Nat Commun. 2023;14(1):5355.

[92] XieL, LiJ, WangG, et al. Phototheranostic metal-phenolic networks with antiexosomal PD-L1 enhanced ferroptosis for synergistic immunotherapy. J Am Chem Soc. 2022;144(2):787-797.

[93] ChenZ, GuoW, TanL, et al. Biomimetic MOF-based nano-immunoactivator via disruption of ion homeostasis for strengthened tumor microwave-immunotherapy. Adv Funct Mater. 2024;2401359.

[94] HuangYK, ChengWC, KuoTT, et al. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nat Cancer. 2024;5(3):400-419.

[95] RenY, MeiL, HuangC, et al. Stereocomplex crystallized nanomedical system for enhanced type I PDT and synergistic chemo-phototherapy. ACS Materials Lett. 2022;5(1):225-234.

[96] ZhanM, QiuJ, FanY, et al. Phosphorous dendron micelles as a nanomedicine platform for cooperative tumor chemoimmunotherapy via synergistic modulation of immune cells. Article Adv Mater. 2023;35(3):2208277.

[97] DuC, GuoX, QiuX, et al. Self-reinforced bimetallic mito-jammer for Ca²⁺ overload-mediated cascade mitochondrial damage for cancer cuproptosis sensitization. Adv Sci. 2024;11(15):2306031.

[98] WangH, WuC, TongX, Chen S. A biomimetic metal-organic framework nanosystem modulates immunosuppressive tumor microenvironment metabolism to amplify immunotherapy. Article J Controlled Release. 2023;353:727-737.

[99] WangX, LuoJ, WangJ, et al. Catalytically active metal-organic frameworks elicit robust immune response to combination chemodynamic and checkpoint blockade immunotherapy. Article ACS Appl Mater Interfaces. 2023;15(5):6442-6455.

[100] YuS, WangC, YuJ, et al. Injectable bioresponsive gel depot for enhanced immune checkpoint blockade. Adv Mater. 2018;30(28):1801527.

[101] Zubieta-OteroLF, Gomez-Vazquez OM, Correa-PiñaBA, Rodriguez-GarciaME. Bio-inspired synthesis of bio-hydroxyapatite/synthetic hydroxyapatite hybrid nanosystems. MedComm -Biomater Appl. 2023;2:e64.

[102] LeiG, ZhuangL, GanB. Targeting ferroptosis as a vulnerability in cancer. Review Nat Rev Cancer. 2022;22(7):381-396.

[103] StockwellBR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185(14):2401-2421.

[104] LiangX, MuM, ChenB, et al. BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer. Mater Today Adv. 2022;16:100308.

[105] MuM, LiangX, ZhaoN, et al. Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor. J Pharm Anal. 2023;13(1):99-109.

[106] LeiG, ZhangY, KoppulaP, et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res. 2020;30(2):146-162.

[107] JiM, LiuH, LiangX, et al. Tumor cells are under siege from all sides: tumor cell-mimic metal-organic framework nanoparticles triggering Cuproptosis/Ferroptosis/Apoptosis for Chemo-Chemodynamic-Photothermal-Immunological synergistic antitumor therapy. Chem Eng J. 2024;485:149640.

[108] YangJ, MaS, XuR, et al. Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy. Article J Controlled Release. 2021;334:21-33.

[109] O’ConnorAE, Gallagher WM, ByrneAT. Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy. Photochem Photobiol. 2009;85(5):1053-1074.

[110] WenK, TanH, PengQ, et al. Achieving efficient NIR-II Type-I photosensitizers for photodynamic/photothermal therapy upon regulating chalcogen elements. Adv Mater. 2022;34(7):2108146.

[111] ZhangS, WangJ, KongZ, et al. Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy. Biomaterials. 2022;282:121433.

[112] ChuanD, HouH, WangYL, et al. Multifunctional metal-polyphenol nanocomposite for melanoma targeted photo/chemodynamic synergistic therapy. J Mater Sci Technol. 2023;152:159-168.

[113] GuoX, TuP, WangX, et al. Decomposable nanoagonists enable NIR-elicited cGAS-STING activation for tandem-amplified photodynamic-metalloimmunotherapy. Adv Mater. 2024;36(21):2313029.

[114] MengX, WuJ, HuZ, ZhengX, WangZ. Coordinating effect of ferroptosis and in situ disulfiram toxification for enhanced cancer therapy. Chem Eng J. 2024;484:149313.

[115] LiY, ZhouJ, ChenY, et al. Near-infrared light-boosted photodynamic-immunotherapy based on sulfonated metal-organic framework nanospindle. Chem Eng J. 2022;437:135370.

[116] WangC, WangJ, PanX, et al. Reversing ferroptosis resistance by MOFs through regulation intracellular redox homeostasis. Asian J Pharm Sci. 2023;18(1):100770.

[117] CaiZ, XinF, WeiZ, et al. Photodynamic therapy combined with antihypoxic signaling and CPG adjuvant as an in situ tumor vaccine based on metal-organic framework nanoparticles to boost cancer immunotherapy. Adv Healthcare Mater. 2020;9(1):1900996.

[118] ZhouS, JiaF, WeiY, et al. Metal-organic framework nanocomposites in conquering hypoxia for tumor therapy. Adv Funct Mater. 2024;34(17):2314012.

[119] WanY, LiC, FuL-H, et al. Erythrocyte membrane camouflaged nanotheranostics for optical molecular imaging-escorted self-oxygenation photodynamic therapy. Small. 2024;20(31):309026.

[120] SunQ, YangJ, ShenW, et al. Engineering mitochondrial uncoupler synergistic photodynamic nanoplatform to harness immunostimulatory pro-death autophagy/mitophagy. Biomaterials. 2022;289:121796.

[121] ChenZ, WuY, YaoZ, et al. 2D copper(II) metalated metal-organic framework nanocomplexes for dual-enhanced photodynamic therapy and amplified antitumor immunity. ACS Appl Mater Interfaces. 2022;14(39):44199-44210.

[122] LiJ, WangS, LinX, et al. Red blood cell-mimic nanocatalyst triggering radical storm to augment cancer immunotherapy. Nano Micro Lett. 2022;14(1):57.

[123] ZhangJ, ChangL, HaoR, et al. Copper/gold-modified porphyrinic metal-organic frameworks nanoprobes for enhanced photodynamic/chemodynamic therapy. Chem Eng J. 2023;474:145485.

[124] LiW, LiR, YeQ, et al. Mn₃O₄ nanoshell coated metal-organic frameworks with microenvironment-driven O₂ production and gsh exhaustion ability for enhanced chemodynamic and photodynamic cancer therapies. Adv Healthcare Mater. 2023;12(15):2202280.

[125] YeJ, ZhangK, YangX, et al. Embedding atomically dispersed manganese/gadolinium dual sites in oxygen vacancy-enriched biodegradable bimetallic silicate nanoplatform for potentiating catalytic therapy. Adv Sci. 2024;11(4):2307424.

[126] YuH, LiY, ZhangZ, et al. Silk fibroin-capped metal-organic framework for tumor-specific redox dyshomeostasis treatment synergized by deoxygenation-driven chemotherapy. Acta Biomater. 2022;138:545-560.

[127] ZhaoX, ZhangK, WangY, et al. Intracellular self-assembly driven nucleus-targeted photo-immune stimulator with chromatin decompaction function for robust innate and adaptive antitumor immunity. Adv Funct Mater. 2022;32(17):2108883.

[128] Abdul RinshadV, SahooJ, VenkateswaruluM, HickeyN, DeM, Sarathi MukherjeeP. Solvent induced conversion of a self-assembled gyrobifastigium to a barrel and encapsulation of zinc-phthalocyanine within the barrel for enhanced photodynamic therapy. Angew Chem Int Ed. 2023;62(14):202218226.

[129] LiangX, MuM, ChenB, et al. Metal-organic framework-based photodynamic combined immunotherapy against the distant development of triple-negative breast cancer. Biomater Res. 2023;27(1):120.

[130] XieBR, YuY, LiuXH, et al. A near infrared ratiometric platform based π-extended porphyrin metal-organic framework for O2 imaging and cancer therapy. Biomaterials. 2021;272:120782.

[131] LuK, HeC, LinW. A chlorin-based nanoscale metal-organic framework for photodynamic therapy of colon cancers. J Am Chem Soc. 2015;137(24):7600-7603.

[132] LuK, HeC, GuoN, et al. Chlorin-based nanoscale metal-organic framework systemically rejects colorectal cancers via synergistic photodynamic therapy and checkpoint blockade immunotherapy. J Am Chem Soc. 2016;138(38):12502-12510.

[133] HuangRX, ZhouPK. DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduct Target Ther. 2020;5(1):60.

[134] ZhaoX, LiY, DuL, DengZ, JiangM, Zeng S. Soft x-ray stimulated lanthanide@MOF nanoprobe for amplifying deep tissue synergistic photodynamic and antitumor immunotherapy. Adv Healthcare Mater. 2021;10(21):2101174.

[135] LiT, GaoM, WuZ, et al. Tantalum-zirconium co-doped metal-organic frameworks sequentially sensitize radio-radiodynamic-immunotherapy for metastatic osteosarcoma. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2023;10(10):2206779.

[136] LuK, HeC, GuoN, et al. Low-dose x-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy. Nat Biomed Eng. 2018;2(8):600-610.

[137] ZhiD, YangT, O’HaganJ, ZhangS, Donnelly RF. Photothermal therapy. J Controlled Release. 2020;325:52-71.

[138] ChuY, XuXQ, WangY. Ultradeep photothermal therapy strategies. J Phys Chem Lett. 2022;13(41):9564-9572.

[139] OverchukM, Weersink RA, WilsonBC, ZhengG. Photodynamic and photothermal therapies: synergy opportunities for nanomedicine. ACS Nano. 2023;17(9):7979-8003.

[140] ZhangX, LuY, JiaD, et al. Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined cancer therapy. J Nanobiotechnol. 2021;19(1):455.

[141] NiW, WuJ, FangH, et al. Photothermal-chemotherapy enhancing tumor immunotherapy by multifunctional metal-organic framework based drug delivery system. Nano Lett. 2021;21(18):7796-7805.

[142] LiuH, XuC, MengM, et al. Metal-organic framework-mediated multifunctional nanoparticles for combined chemo-photothermal therapy and enhanced immunotherapy against colorectal cancer. Acta Biomater. 2022;144:132-141.

[143] WangY, ChenZ, LiJ, et al. A paramagnetic metal-organic framework enhances mild magnetic hyperthermia therapy by downregulating heat shock proteins and promoting ferroptosis via aggravation of two-way regulated redox dyshomeostasis. Adv Sci. 2024;11(11):2306178.

[144] GuoW, NiuM, ChenZ, et al. Programmed upregulation of HSP70 by metal-organic frameworks nanoamplifier for enhanced microwave thermal-immunotherapy. Adv Healthcare Mater. 2022;11(23):2201441.

[145] YangY, HuangJ, LiuM, et al. Emerging sonodynamic therapy-based nanomedicines for cancer immunotherapy. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2023;10(2):2204365.

[146] LiaoD, HuangJ, JiangC, et al. A novel platform of MOF for sonodynamic therapy advanced therapies. Pharmaceutics. 2023;15(8):2071.

[147] WangC, ChenL, ZhuJ, et al. Programmable bacteria-based biohybrids as living biotherapeutics for enhanced cancer sonodynamic-immunotherapy. Adv Funct Mater. 2024;34(30):2316092.

[148] ZhouL, FengW, MaoY, ChenY, ZhangX. Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis. Bioactive Mater. 2023;24:26-36.

[149] LiuR, YangJ, DuY, et al. A “one arrow three eagle” strategy to improve CM-272 primed bladder cancer immunotherapy. Adv Mater. 2023;36(9):2310522.

[150] ZhanG, XuQ, ZhangZ, et al. Biomimetic sonodynamic therapy-nanovaccine integration platform potentiates Anti-PD-1 therapy in hypoxic tumors. Nano Today. 2021;38:101195.

[151] LuoJ, WangX, ShiZ, et al. Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy. J Nanobiotechnol. 2022;20(1):228.

[152] SunT, LiJ, ZhouY, et al. Metal-organic framework-mediated synergistic hypoxia-activated chemo-immunotherapy induced by high intensity focused ultrasound for enhanced cancer theranostics. Small. 2024;20(18):2306338.

[153] MaY, WuM, MoF, ChenZ, LuJ, SunD. Enhanced electrochemical characterization of the immune checkpoint protein pd-l1 using aptamer-functionalized magnetic metal-organic frameworks. Adv Healthcare Mater. 2024;13(9):2303103.

[154] FengJ, JiaL, PanW, et al. Rapid and efficient fluorescent aptasensor for PD-L1 positive extracellular vesicles isolation and analysis: EV-ANCHOR. Chem Eng J. 2023;465:142811.

[155] WangQ-X, YangY-F, YangX-F, et al. Upconverted/downshifted NaLnF₄ and metal-organic framework heterostructures boosting NIR-II imaging-guided photodynamic immunotherapy toward tumors. Nano Today. 2022;43:101439.

[156] LiuD, LiangM, TaoY, et al. Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy. Biomaterials. 2024;309:122610.

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2024 The Author(s). MedComm - Biomaterials and Applications published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).