USP10 deubiquitylates and stabilizes DIRAS2 to suppress the growth of pancreatic cancer cells

Qian Chen , Xiufang Xiong , Yi Sun

MedComm ›› 2024, Vol. 5 ›› Issue (10) : e751

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MedComm ›› 2024, Vol. 5 ›› Issue (10) : e751 DOI: 10.1002/mco2.751
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USP10 deubiquitylates and stabilizes DIRAS2 to suppress the growth of pancreatic cancer cells

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Qian Chen, Xiufang Xiong, Yi Sun. USP10 deubiquitylates and stabilizes DIRAS2 to suppress the growth of pancreatic cancer cells. MedComm, 2024, 5(10): e751 DOI:10.1002/mco2.751

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References

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Dewson G, Eichhorn PJA, Komander D. Deubiquitinases in cancer. Nat Rev Cancer. 2023; 23(12): 842-862.

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Kontani K, Tada M, Ogawa T, et al. Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. J Biol Chem. 2002; 277(43): 41070-41078.

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Sutton MN, Lu Z, Li YC, et al. DIRAS3 (ARHI) blocks RAS/MAPK signaling by binding directly to RAS and disrupting RAS clusters. Cell Rep. 2019; 29(11): 3448-3459. e3446.

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Chang Y, Chen Q, Li H, et al. The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Dev Cell. 1315; 59(10): 1317-1332.

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Wang X, Xia S, Li H, et al. The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis. Cell Death Differ. 2020; 27(6): 1747-1764.

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2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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