Development of a Trivalent Seasonal Influenza Vaccine Using Long α-Helix-Mediated Trimeric HA1 Proteins Produced in Baculovirus-Insect Cell System

Ning Guo , Zhibin Xu , Xinyu Chen , Xiaonan Han , Ting Xue , Jinghua Yan , Qingrui Huang

MedComm ›› 2026, Vol. 7 ›› Issue (8) : e70880

PDF (829KB)
MedComm ›› 2026, Vol. 7 ›› Issue (8) :e70880 DOI: 10.1002/mco2.70880
LETTER
Development of a Trivalent Seasonal Influenza Vaccine Using Long α-Helix-Mediated Trimeric HA1 Proteins Produced in Baculovirus-Insect Cell System
Author information +
History +
PDF (829KB)

Cite this article

Download citation ▾
Ning Guo, Zhibin Xu, Xinyu Chen, Xiaonan Han, Ting Xue, Jinghua Yan, Qingrui Huang. Development of a Trivalent Seasonal Influenza Vaccine Using Long α-Helix-Mediated Trimeric HA1 Proteins Produced in Baculovirus-Insect Cell System. MedComm, 2026, 7 (8) : e70880 DOI:10.1002/mco2.70880

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

A. Chatterjee, K. Ambrose, D. H. Canaday, et al., “The Association Between Influenza Vaccine Effectiveness and Egg-based Manufacturing Technology: Literature Review and US Expert Consensus,” Current Medical Research and Opinion 40 (2023): 335–343.

[2]

M. M. Cox, P. A. Patriarca, and J. Treanor, “FluBlok, a Recombinant Hemagglutinin Influenza Vaccine,” Influenza and Other Respiratory Viruses 2 (2009): 211–219.

[3]

R. Shi, J. Zeng, L. Xu, et al., “A Combination Vaccine Against SARS-CoV-2 and H1N1 Influenza Based on Receptor Binding Domain Trimerized by Six-helix Bundle Fusion Core,” EBioMedicine 85 (2022): 104297.

[4]

S. Bangaru, S. Lang, M. Schotsaert, et al., “A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface,” Cell 177 (2019): 1136–1152.

[5]

M. G. Alameh, I. Tombácz, E. Bettini, et al., “Lipid Nanoparticles Enhance the Efficacy of mRNA and Protein Subunit Vaccines by Inducing Robust T Follicular Helper Cell and Humoral Responses,” Immunity 54 (2021): 1136–1138.

Rights & permissions

2026 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

PDF (829KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/

〈 〉