Rezatapopt and the Return of Targetable p53

Yuanze Luo , Assam El-Osta

MedComm ›› 2026, Vol. 7 ›› Issue (7) : e70842

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MedComm ›› 2026, Vol. 7 ›› Issue (7) :e70842 DOI: 10.1002/mco2.70842
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Rezatapopt and the Return of Targetable p53
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Yuanze Luo, Assam El-Osta. Rezatapopt and the Return of Targetable p53. MedComm, 2026, 7 (7) : e70842 DOI:10.1002/mco2.70842

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References

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E. E. Dumbrava, G. I. Shapiro, A. R. Parikh, et al., “Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C-Mutated Tumors,” New England Journal of Medicine 394, no. 9 (2026): 872–883.

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D. P. Lane, “Cancer. P53, Guardian of the Genome,” Nature 358, no. 6381 (1992): 15–16.

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A. J. Levine, J. Momand, and C. A. Finlay, “The p53 Tumour Suppressor Gene,” Nature 351, no. 6326 (1991): 453–456.

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K. H. Vousden and D. P. Lane, “p53 in Health and Disease,” Nature Reviews Molecular Cell Biology 8, no. 4 (2007): 275–283.

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J. Momand, G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine, “The Mdm-2 Oncogene Product Forms a Complex with the p53 Protein and Inhibits p53-Mediated Transactivation,” Cell 69, no. 7 (1992): 1237–1245.

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2026 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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