msDNA: A “Wake-on Sensor” for Defense Effectors in Prokaryotic Retron Systems

Hongbiao Ran; Min Wu; Ping Lin

doi:10.1002/mco2.70758

MedComm ›› 2026, Vol. 7 ›› Issue (5) :e70758 DOI: 10.1002/mco2.70758

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msDNA: A “Wake-on Sensor” for Defense Effectors in Prokaryotic Retron Systems

Hongbiao Ran ¹^,²
, Min Wu ²^,³
, Ping Lin ¹

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Hongbiao Ran, Min Wu, Ping Lin. msDNA: A “Wake-on Sensor” for Defense Effectors in Prokaryotic Retron Systems. MedComm, 2026, 7 (5) : e70758 DOI:10.1002/mco2.70758

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References

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[1]	L. Yuan, L. Xu, B. Wu, et al., “Molecular Mechanism of Eco8-mediated Anti-phage Defense,” Molecular Cell 85, no. 22 (2025): 4229–4242.e4.

[2]	C. Yu, C. Wang, T. Forman, et al., “Phage SSB Detection by Retron Eco8 msDNA Unleashes Nuclease-mediated Immunity,” Molecular Cell 85, no. 22 (2025): 4243–4253.e4.

[3]	A. Millman, A. Bernheim, A. Stokar-Avihail, et al., “Bacterial Retrons Function in Anti-Phage Defense,” Cell 183, no. 6 (2020): 1551–1561.e12.

[4]	Y. Wang, C. Wang, Z. Guan, et al., “DNA Methylation Activates Retron Ec86 filaments for Antiphage Defense,” Cell reports 43, no. 10 (2024): 114857.

[5]	C. Wang, A. D. Rish, E. G. Armbruster, et al., “Disassembly Activates Retron-Septu for Antiphage Defense,” Science 389, no. 6762 (2025): eadv3344.

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2026 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.