Targeting ApoA5-Associated Hypertriglyceridemia to Ameliorate Acute Pancreatitis: Insights From a Knockout Hamster Model

Sijing Shi; Kaikai Lu; Yijun Tao; Yue Zhang; Ling Zhang; George Liu; Wei Huang; Yuhui Wang; Xunde Xian

doi:10.1002/mco2.70555

MedComm ›› 2025, Vol. 6 ›› Issue (12) :e70555 DOI: 10.1002/mco2.70555

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Targeting ApoA5-Associated Hypertriglyceridemia to Ameliorate Acute Pancreatitis: Insights From a Knockout Hamster Model

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Sijing Shi, Kaikai Lu, Yijun Tao, Yue Zhang, Ling Zhang, George Liu, Wei Huang, Yuhui Wang, Xunde Xian. Targeting ApoA5-Associated Hypertriglyceridemia to Ameliorate Acute Pancreatitis: Insights From a Knockout Hamster Model. MedComm, 2025, 6(12): e70555 DOI:10.1002/mco2.70555

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References

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[1]	M. Paquette, S. P. Guay, and A. Baass, “Genetic Determinants of Pancreatitis Risk in Hypertriglyceridemia,” Current Opinion in Lipidology 36, no. 2 (2025): 55–60.

[2]	Z. Huang, L. Wen, C. Huang, et al., “SRA1, APOA5, and AIFM2 Identified as Novel Genetic Risk Factors in Recurrent Hypertriglyceridemia-associated Acute Pancreatitis by Whole-exome Sequencing,” Chinese Medical Journal (2025).

[3]	J. Guo, G. Miao, W. Zhang, et al., “Depletion of ApoA5 Aggravates Spontaneous and Diet-induced Nonalcoholic Fatty Liver Disease by Reducing Hepatic NR1D1 in Hamsters,” Theranostics 14, no. 5 (2024): 2036–2057.

[4]	Y. Wang, A. Kayoumu, G. Lu, et al., “Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis,” Scientific Reports 6 (2016): 28014.

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