A Phase II Study of Sitravatinib Combined With Tislelizumab Plus Docetaxel for Acquired Resistance to PD-(L)1 in Patients With Advanced/Metastatic Non-Small Cell Lung Cancer

Yalun Li , Jin Zhou , Li Jiang , Hua Xie , Zonglian Gong , Ke Wang , Yan Zhang , Yan Li , Weimin Li , Panwen Tian

MedComm ›› 2025, Vol. 6 ›› Issue (12) : e70538

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MedComm ›› 2025, Vol. 6 ›› Issue (12) :e70538 DOI: 10.1002/mco2.70538
ORIGINAL ARTICLE
A Phase II Study of Sitravatinib Combined With Tislelizumab Plus Docetaxel for Acquired Resistance to PD-(L)1 in Patients With Advanced/Metastatic Non-Small Cell Lung Cancer
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Abstract

Trial registration: Chictr.org.cn, ChiCTR2200065547. Registered in 2022-11-08, https://www.chictr.org.cn/showproj.html?proj=183439.

Keywords

acquired resistance / CD4+ T cell / immunotherapy / single-cell secretome proteomics / TCR sequencing

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Yalun Li, Jin Zhou, Li Jiang, Hua Xie, Zonglian Gong, Ke Wang, Yan Zhang, Yan Li, Weimin Li, Panwen Tian. A Phase II Study of Sitravatinib Combined With Tislelizumab Plus Docetaxel for Acquired Resistance to PD-(L)1 in Patients With Advanced/Metastatic Non-Small Cell Lung Cancer. MedComm, 2025, 6(12): e70538 DOI:10.1002/mco2.70538

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