Non-stoichiometric Sodium Chloride Reprograms Ionic Homeostasis to Enhance Antitumor Immunity

Chongxiao Wang; Yuan Deng; Heng Liang; Arabella H. Wan; Shijia Yan; Min Xiao; Chuwei Liu; Juan Fang; Zhi Wang; Guohui Wan

doi:10.1002/mco2.70534

MedComm ›› 2025, Vol. 6 ›› Issue (12) :e70534 DOI: 10.1002/mco2.70534

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Non-stoichiometric Sodium Chloride Reprograms Ionic Homeostasis to Enhance Antitumor Immunity

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Chongxiao Wang, Yuan Deng, Heng Liang, Arabella H. Wan, Shijia Yan, Min Xiao, Chuwei Liu, Juan Fang, Zhi Wang, Guohui Wan. Non-stoichiometric Sodium Chloride Reprograms Ionic Homeostasis to Enhance Antitumor Immunity. MedComm, 2025, 6(12): e70534 DOI:10.1002/mco2.70534

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References

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[2]	S. Feske, E. Y. Skolnik, and M. Prakriya, “Ion Channels and Transporters in Lymphocyte Function and Immunity,” Nature Reviews Immunology 12 (2012): 532–547.

[3]	D. Soll, C. F. Chu, S. Sun, et al., “Sodium Chloride in the Tumor Microenvironment Enhances T Cell Metabolic Fitness and Cytotoxicity,” Nature Immunology 25 (2024): 1830–1844.

[4]	C. Scirgolea, R. Sottile, M. De Luca, et al., “NaCl Enhances CD8(+) T Cell Effector Functions in Cancer Immunotherapy,” Nature Immunology 25 (2024): 1845–1857.

[5]	K. Yang, Z. Li, Y. Chen, et al., “Na, K-ATPase alpha1 Cooperates With Its Endogenous Ligand to Reprogram Immune Microenvironment of Lung Carcinoma and Promotes Immune Escape,” Science Advances 9 (2023): eade5393.

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